Browsing by Author "Borgnia, Mario J"
Now showing items 1-5 of 5
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Correction: Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies.
(PLoS pathogens, 2019-12-02)[This corrects the article DOI: 10.1371/journal.ppat.1008026.]. -
Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.
(Cell, 2021-05-18)Natural antibodies (Abs) can target host glycans on the surface of pathogens. We studied the evolution of glycan-reactive B cells of rhesus macaques and humans using glycosylated HIV-1 envelope (Env) as a model antigen. ... -
Regulatory switch at the cytoplasmic interface controls TRPV channel gating.
(eLife, 2019-05-09)Temperature-sensitive transient receptor potential vanilloid (thermoTRPV) channels are activated by ligands and heat, and are involved in various physiological processes. ThermoTRPV channels possess a large cytoplasmic ring ... -
Structure and dynamics of the Arabidopsis O-fucosyltransferase SPINDLY.
(Nature communications, 2023-03)SPINDLY (SPY) in Arabidopsis thaliana is a novel nucleocytoplasmic protein O-fucosyltransferase (POFUT), which regulates diverse developmental processes. Sequence analysis indicates that SPY is distinct from ER-localized ... -
Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.
(eLife, 2019-05-15)The Transient Receptor Potential Vanilloid 2 (TRPV2) channel is a member of the temperature-sensing thermoTRPV family. Recent advances in cryo-electronmicroscopy (cryo-EM) and X-ray crystallography have provided many important ...
