Now showing items 1-4 of 4

    • Origin and evolution of HIV-1 in breast milk determined by single-genome amplification and sequencing. 

      Borrow, P; Center for HIV/AIDS Vaccine Immunology A0167854; Denny, Thomas Norton; Fouda, Genevieve; Hahn, Beatrice H; Kalilani, L; Kang, HH; ... (19 authors) (J Virol, 2011-03)
      HIV transmission via breastfeeding accounts for a considerable proportion of infant HIV acquisition. However, the origin and evolution of the virus population in breast milk, the likely reservoir of transmitted virus variants, ...
    • Phenotypic properties of transmitted founder HIV-1. 

      Barbian, HJ; Berg, A; Bhardwaj, N; Bjorkman, PJ; Borrow, P; Cai, Fangping; Decker, JM; ... (31 authors) (Proc Natl Acad Sci U S A, 2013-04-23)
      Defining the virus-host interactions responsible for HIV-1 transmission, including the phenotypic requirements of viruses capable of establishing de novo infections, could be important for AIDS vaccine development. Previous ...
    • The magnitude and kinetics of the mucosal HIV-specific CD8+ T lymphocyte response and virus RNA load in breast milk. 

      Borrow, P; Bunn, JEG; Center for HIV/AIDS Vaccine Immunology; Denny, Thomas Norton; Goonetilleke, N; Kalilani, L; Kang, HH; ... (13 authors) (PLoS One, 2011)
      BACKGROUND: The risk of postnatal HIV transmission is associated with the magnitude of the milk virus load. While HIV-specific cellular immune responses control systemic virus load and are detectable in milk, the contribution ...
    • Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencing. 

      Bhattacharya, T; Borrow, P; Fischer, W; Ganusov, VV; Giorgi, EE; Gleasner, CD; Green, L; ... (21 authors) (PLoS One, 2010-08-20)
      We used ultra-deep sequencing to obtain tens of thousands of HIV-1 sequences from regions targeted by CD8+ T lymphocytes from longitudinal samples from three acutely infected subjects, and modeled viral evolution during ...