Now showing items 1-6 of 6

    • Elevation of intact and proteolytic fragments of acute phase proteins constitutes the earliest systemic antiviral response in HIV-1 infection. 

      Kramer, Holger B; Lavender, Kerry J; Qin, Li; Stacey, Andrea R; Liu, Michael KP; di Gleria, Katalin; Simmons, Alison; ... (12 authors) (PLoS pathogens, 2010)
      The earliest immune responses activated in acute human immunodeficiency virus type 1 infection (AHI) exert a critical influence on subsequent virus spread or containment. During this time frame, components of the innate ...
    • Immune checkpoint modulation enhances HIV-1 antibody induction. 

      Bradley, Todd; Kuraoka, Masayuki; Yeh, Chen-Hao; Tian, Ming; Chen, Huan; Cain, Derek W; Chen, Xuejun; ... (30 authors) (Nature communications, 2020-02-19)
      Eliciting protective titers of HIV-1 broadly neutralizing antibodies (bnAbs) is a goal of HIV-1 vaccine development, but current vaccine strategies have yet to induce bnAbs in humans. Many bnAbs isolated from HIV-1-infected ...
    • Origin and evolution of HIV-1 in breast milk determined by single-genome amplification and sequencing. 

      Salazar-Gonzalez, Jesus F; Salazar, Maria G; Learn, Gerald H; Fouda, Genevieve G; Kang, Helen H; Mahlokozera, Tatenda; Wilks, Andrew B; ... (19 authors) (J Virol, 2011-03)
      HIV transmission via breastfeeding accounts for a considerable proportion of infant HIV acquisition. However, the origin and evolution of the virus population in breast milk, the likely reservoir of transmitted virus variants, ...
    • Phenotypic properties of transmitted founder HIV-1. 

      Parrish, Nicholas F; Gao, Feng; Li, Hui; Giorgi, Elena E; Barbian, Hannah J; Parrish, Erica H; Zajic, Lara; ... (32 authors) (Proc Natl Acad Sci U S A, 2013-04-23)
      Defining the virus-host interactions responsible for HIV-1 transmission, including the phenotypic requirements of viruses capable of establishing de novo infections, could be important for AIDS vaccine development. Previous ...
    • The magnitude and kinetics of the mucosal HIV-specific CD8+ T lymphocyte response and virus RNA load in breast milk. 

      Mahlokozera, Tatenda; Kang, Helen H; Goonetilleke, Nilu; Stacey, Andrea R; Lovingood, Rachel V; Denny, Thomas N; Kalilani, Linda; ... (13 authors) (PLoS One, 2011)
      BACKGROUND: The risk of postnatal HIV transmission is associated with the magnitude of the milk virus load. While HIV-specific cellular immune responses control systemic virus load and are detectable in milk, the contribution ...
    • Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencing. 

      Fischer, Will; Ganusov, Vitaly V; Giorgi, Elena E; Hraber, Peter T; Keele, Brandon F; Leitner, Thomas; Han, Cliff S; ... (21 authors) (PLoS One, 2010-08-20)
      We used ultra-deep sequencing to obtain tens of thousands of HIV-1 sequences from regions targeted by CD8+ T lymphocytes from longitudinal samples from three acutely infected subjects, and modeled viral evolution during ...