Browsing by Author "Bowles, Dawn E"

Now showing items 1-4 of 4

    • An isolated working heart system for large animal models. 

      Schechter, Matthew A; Southerland, Kevin W; Feger, Bryan J; Linder, Dean; Ali, Ayyaz A; Njoroge, Linda; Milano, Carmelo A; ... (8 authors) (J Vis Exp, 2014-06-11)
      Since its introduction in the late 19(th) century, the Langendorff isolated heart perfusion apparatus, and the subsequent development of the working heart model, have been invaluable tools for studying cardiovascular function ...

    • Microgravity induces proteomics changes involved in endoplasmic reticulum stress and mitochondrial protection. 

      Feger, Bryan J; Thompson, J Will; Dubois, Laura G; Kommaddi, Reddy P; Foster, Matthew W; Mishra, Rajashree; Shenoy, Sudha K; ... (12 authors) (Scientific reports, 2016-09-27)
      On Earth, biological systems have evolved in response to environmental stressors, interactions dictated by physical forces that include gravity. The absence of gravity is an extreme stressor and the impact of its absence ...

    • Phosphoproteomic profiling of human myocardial tissues distinguishes ischemic from non-ischemic end stage heart failure. 

      Schechter, Matthew A; Hsieh, Michael KH; Njoroge, Linda W; Thompson, J Will; Soderblom, Erik J; Feger, Bryan J; Troupes, Constantine D; ... (20 authors) (PLoS One, 2014)
      The molecular differences between ischemic (IF) and non-ischemic (NIF) heart failure are poorly defined. A better understanding of the molecular differences between these two heart failure etiologies may lead to the development ...

    • Utility of telomerase-pot1 fusion protein in vascular tissue engineering. 

      Petersen, Thomas H; Hitchcock, Thomas; Muto, Akihito; Calle, Elizabeth A; Zhao, Liping; Gong, Zhaodi; Gui, Liqiong; ... (11 authors) (Cell Transplant, 2010)
      While advances in regenerative medicine and vascular tissue engineering have been substantial in recent years, important stumbling blocks remain. In particular, the limited life span of differentiated cells that are harvested ...