Browsing by Author "Brian, Leigh"

Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration.

Kim, Jihee; Zhang, Lisheng; Peppel, Karsten; Wu, Jiao-Hui; Zidar, David A; Brian, Leigh; DeWire, Scott M; ... (10 authors) (Circ Res, 2008-07-03)

Atherosclerosis and arterial injury-induced neointimal hyperplasia involve medial smooth muscle cell (SMC) proliferation and migration into the arterial intima. Because many 7-transmembrane and growth factor receptors promote ...

Drebrin attenuates atherosclerosis by limiting smooth muscle cell transdifferentiation.

Wu, Jiao-Hui; Zhang, Lisheng; Nepliouev, Igor; Brian, Leigh; Huang, Taiqin; Snow, Kamie P; Schickling, Brandon M; ... (11 authors) (Cardiovascular research, 2021-04-29)

<h4>Aims</h4>The F-actin-binding protein Drebrin inhibits smooth muscle cell (SMC) migration, proliferation and pro-inflammatory signaling. Therefore, we tested the hypothesis that Drebrin constrains atherosclerosis.<h4>Methods ...

Interleukin-9 mediates chronic kidney disease-dependent vein graft disease: a role for mast cells.

Zhang, Lisheng; Wu, Jiao-Hui; Otto, James C; Gurley, Susan B; Hauser, Elizabeth R; Shenoy, Sudha K; Nagi, Karim; ... (12 authors) (Cardiovasc Res, 2017-11-01)

Aims: Chronic kidney disease (CKD) is a powerful independent risk factor for cardiovascular events, including vein graft failure. Because CKD impairs the clearance of small proteins, we tested the hypothesis that CKD exacerbates ...