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    • Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis. 

      Bunte, RM; Crowley, Steven Daniel; Griffiths, Robert; Madan, B; Patel, MB; Rudemiller, Nathan P; Virshup, DM; ... (8 authors) (Kidney Int, 2016-05)
      Activated Wnt signaling is critical in the pathogenesis of renal fibrosis, a final common pathway for most forms of chronic kidney disease. Therapeutic intervention by inhibition of individual Wnts or downstream Wnt/β-catenin ...