Now showing items 1-6 of 6

    • Intravital imaging of mouse embryos 

      Huang, Qiang; Cohen, Malkiel A; Alsina, Fernando C; Devlin, Garth; Garrett, Aliesha; McKey, Jennifer; Havlik, Patrick; ... (27 authors) (Science, 2020-04-10)
      <jats:p>Embryonic development is a complex process that is unamenable to direct observation. In this study, we implanted a window to the mouse uterus to visualize the developing embryo from embryonic day 9.5 to birth. This ...
    • Oestrogen shuts the door on SOX9. 

      Mork, Lindsey; Capel, Blanche (BMC Biol, 2010-08-31)
      Oestrogen exerts a robust yet imperfectly understood effect on sexual development in vertebrate embryos. New work by Pask and colleagues in BMC Biology indicates that it may interfere with male development by preventing ...
    • Regulation of male germ cell cycle arrest and differentiation by DND1 is modulated by genetic background 

      Cook, Matthew S; Munger, Steven C; Nadeau, Joseph H; Capel, Blanche (2011)
      Human germ cell tumors show a strong sensitivity to genetic background similar to Dnd1(Ter/Ter) mutant mice, where testicular teratomas arise only on the 129/SvJ genetic background. The introduction of the Bax mutation onto ...
    • The RNA-binding protein DND1 acts Sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming. 

      Ruthig, Victor A; Friedersdorf, Matthew B; Garness, Jason A; Munger, Steve C; Bunce, Corey; Keene, Jack D; Capel, Blanche (Development (Cambridge, England), 2019-06-28)
      The adult spermatogonial stem cell population arises from pluripotent primordial germ cells (PGCs) that enter the fetal testis around embryonic day (E)10.5. PGCs undergo rapid mitotic proliferation, then enter prolonged ...
    • To Be or Not To Be a Testis. 

      Capel, Blanche (Reproduction (Cambridge, England), 2019-07)
      Work that established the testis as the driver of male development, and the Y-chromosome as the bearer of the male-determining gene, established a working model, and set the stage for the molecular age of mammalian ...
    • Unmasking a role for sex chromosomes in gene silencing. 

      Maatouk, Danielle M; Capel, Blanche (Genome Biol, 2010)
      Several sexually dimorphic phenotypes correlate with sex-chromosome dosage rather than with phenotypic sex. New research suggests that sex chromosome dimorphism helps to regulate gene silencing.