Browsing by Author "Caron, Marc G"
Now showing items 1-6 of 6
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Biased agonists of the chemokine receptor CXCR3 differentially signal through Gαi:β-arrestin complexes.
(Science signaling, 2022-03-22)G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors and signal through the proximal effectors, G proteins and β-arrestins, to influence nearly every biological process. The G protein and ... -
Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice.
(J Neurosci, 2002-12-01)Morphine induces antinociception by activating mu opioid receptors (muORs) in spinal and supraspinal regions of the CNS. (Beta)arrestin-2 (beta)arr2), a G-protein-coupled receptor-regulating protein, regulates the muOR in ... -
Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice.
(J Neurosci, 2003-11-12)The reinforcing and psychomotor effects of morphine involve opiate stimulation of the dopaminergic system via activation of mu-opioid receptors (muOR). Both mu-opioid and dopamine receptors are members of the G-protein-coupled ... -
Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance.
(J Neurosci, 2004-05-12)Release of endogenous dynorphin opioids within the spinal cord after partial sciatic nerve ligation (pSNL) is known to contribute to the neuropathic pain processes. Using a phosphoselective antibody [kappa opioid receptor ... -
The dopamine metabolite 3-methoxytyramine is a neuromodulator.
(PLoS One, 2010-10-18)Dopamine (3-hydroxytyramine) is a well-known catecholamine neurotransmitter involved in multiple physiological functions including movement control. Here we report that the major extracellular metabolite of dopamine, ... -
The role of GRK6 in animal models of Parkinson's disease and L-DOPA treatment.
(Sci Rep, 2012)G protein-coupled Receptor Kinase 6 (GRK6) belongs to a family of kinases that phosphorylate GPCRs. GRK6 levels were found to be altered in Parkinson's Disease (PD) and D(2) dopamine receptors are supersensitive in mice ...
