Now showing items 1-10 of 10

    • A longitudinal study of epigenetic variation in twins. 

      Wong, Chloe Chung Yi; Caspi, Avshalom; Williams, Benjamin; Craig, Ian W; Houts, Renate; Ambler, Antony; Moffitt, Terrie E; ... (8 authors) (Epigenetics, 2010-08-16)
      DNA methylation is a key epigenetic mechanism involved in the developmental regulation of gene expression. Alterations in DNA methylation are established contributors to inter-individual phenotypic variation and have been ...
    • Cardiorespiratory fitness and cognitive function in midlife: neuroprotection or neuroselection? 

      Belsky, Daniel W; Caspi, Avshalom; Israel, Salomon; Blumenthal, James A; Poulton, Richie; Moffitt, Terrie E (Ann Neurol, 2015-04)
      OBJECTIVE: A study was undertaken to determine whether better cognitive functioning at midlife among more physically fit individuals reflects neuroprotection, by which fitness protects against age-related cognitive decline, ...
    • Childhood forecasting of a small segment of the population with large economic burden. 

      Caspi, Avshalom; Houts, Renate M; Belsky, Daniel W; Harrington, Honalee; Hogan, Sean; Ramrakha, Sandhya; Poulton, Richie; ... (8 authors) (Nat Hum Behav, 2016)
      Policy-makers are interested in early-years interventions to ameliorate childhood risks. They hope for improved adult outcomes in the long run, bringing return on investment. How much return can be expected depends, partly, ...
    • Credit scores, cardiovascular disease risk, and human capital. 

      Israel, Salomon; Caspi, Avshalom; Belsky, Daniel W; Harrington, HonaLee; Hogan, Sean; Houts, Renate; Ramrakha, Sandhya; ... (10 authors) (Proc Natl Acad Sci U S A, 2014-12-02)
      Credit scores are the most widely used instruments to assess whether or not a person is a financial risk. Credit scoring has been so successful that it has expanded beyond lending and into our everyday lives, even to inform ...
    • General functional connectivity: Shared features of resting-state and task fMRI drive reliable and heritable individual differences in functional brain networks. 

      Elliott, Maxwell L; Knodt, Annchen R; Cooke, Megan; Kim, M Justin; Melzer, Tracy R; Keenan, Ross; Ireland, David; ... (12 authors) (NeuroImage, 2019-04)
      Intrinsic connectivity, measured using resting-state fMRI, has emerged as a fundamental tool in the study of the human brain. However, due to practical limitations, many studies do not collect enough resting-state data to ...
    • Is chronic asthma associated with shorter leukocyte telomere length at midlife? 

      Belsky, Daniel W; Shalev, Idan; Sears, Malcolm R; Hancox, Robert J; Lee Harrington, Hona; Houts, Renate; Moffitt, Terrie E; ... (11 authors) (Am J Respir Crit Care Med, 2014-08-15)
      RATIONALE: Asthma is prospectively associated with age-related chronic diseases and mortality, suggesting the hypothesis that asthma may relate to a general, multisystem phenotype of accelerated aging. OBJECTIVES: To test ...
    • Quantification of biological aging in young adults. 

      Belsky, Daniel W; Caspi, Avshalom; Houts, Renate; Cohen, Harvey J; Corcoran, David L; Danese, Andrea; Harrington, HonaLee; ... (15 authors) (Proc Natl Acad Sci U S A, 2015-07-28)
      Antiaging therapies show promise in model organism research. Translation to humans is needed to address the challenges of an aging global population. Interventions to slow human aging will need to be applied to still-young ...
    • Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm. 

      Belsky, Daniel W; Caspi, Avshalom; Arseneault, Louise; Baccarelli, Andrea; Corcoran, David L; Gao, Xu; Hannon, Eiliss; ... (22 authors) (eLife, 2020-05-05)
      Biological aging is the gradual, progressive decline in system integrity that occurs with advancing chronological age, causing morbidity and disability. Measurements of the pace of aging are needed as surrogate endpoints ...
    • The Genetics of Success: How Single-Nucleotide Polymorphisms Associated With Educational Attainment Relate to Life-Course Development. 

      Belsky, Daniel W; Moffitt, Terrie E; Corcoran, David L; Domingue, Benjamin; Harrington, HonaLee; Hogan, Sean; Houts, Renate; ... (12 authors) (Psychol Sci, 2016-07)
      A previous genome-wide association study (GWAS) of more than 100,000 individuals identified molecular-genetic predictors of educational attainment. We undertook in-depth life-course investigation of the polygenic score derived ...
    • What Is the Test-Retest Reliability of Common Task-Functional MRI Measures? New Empirical Evidence and a Meta-Analysis. 

      Elliott, Maxwell L; Knodt, Annchen R; Ireland, David; Morris, Meriwether L; Poulton, Richie; Ramrakha, Sandhya; Sison, Maria L; ... (10 authors) (Psychological science, 2020-07)
      Identifying brain biomarkers of disease risk is a growing priority in neuroscience. The ability to identify meaningful biomarkers is limited by measurement reliability; unreliable measures are unsuitable for predicting clinical ...