Browsing by Author "Chambers, Henry F"

Analytical Evaluation of the Abbott RealTime CT/NG Assay for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae in Rectal and Pharyngeal Swabs.

Adamson, Paul C; Pandori, Mark W; Doernberg, Sarah B; Komarow, Lauren; Sund, Zoe; Tran, Thuy Tien T; Jensen, David; ... (15 authors) (The Journal of molecular diagnostics : JMD, 2020-06)

Chlamydia trachomatis and Neisseria gonorrhoeae infections in the rectum and pharynx are important extragenital reservoirs of infection. Few assays approved by the US Food and Drug Administration are commercially available ...

Antibacterial Resistance Leadership Group 2.0: Back to Business.

Chambers, Henry F; Evans, Scott R; Patel, Robin; Cross, Heather R; Harris, Anthony D; Doi, Yohei; Boucher, Helen W; ... (15 authors) (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021-08)

In December 2019, the Antibacterial Resistance Leadership Group (ARLG) was awarded funding for another 7-year cycle to support a clinical research network on antibacterial resistance. ARLG 2.0 has 3 overarching research ...

Can ceftazidime/avibactam and aztreonam overcome β-lactam resistance conferred by metallo-β-lactamases in Enterobacteriaceae?

Marshall, Steven; Hujer, Andrea M; Rojas, Laura J; Papp-Wallace, Krisztina M; Humphries, Romney M; Spellberg, Brad; Hujer, Kristine M; ... (23 authors) (Antimicrob Agents Chemother, 2017-02-06)

Based upon knowledge of the hydrolytic profile of major β-lactamases found in Gram negative bacteria, we tested the effectiveness of the combination of ceftazidime/avibactam (CAZ/AVI) with aztreonam (ATM) against ...

Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study.

Wang, Minggui; Earley, Michelle; Chen, Liang; Hanson, Blake M; Yu, Yunsong; Liu, Zhengyin; Salcedo, Soraya; ... (40 authors) (The Lancet. Infectious diseases, 2021-11-09)

<h4>Background</h4>Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a global threat. We therefore analysed the bacterial characteristics of CRKP infections and the clinical outcomes of patients with CRKP infections across ...

Short- vs Standard-Course Outpatient Antibiotic Therapy for Community-Acquired Pneumonia in Children: The SCOUT-CAP Randomized Clinical Trial.

Williams, Derek J; Creech, C Buddy; Walter, Emmanuel B; Martin, Judith M; Gerber, Jeffrey S; Newland, Jason G; Howard, Lee; ... (21 authors) (JAMA pediatrics, 2022-01-18)

<h4>Importance</h4>Childhood community-acquired pneumonia (CAP) is usually treated with 10 days of antibiotics. Shorter courses may be effective with fewer adverse effects and decreased potential for antibiotic ...

Simultaneous Evaluation of Diagnostic Assays for Pharyngeal and Rectal Neisseria gonorrhoeae and Chlamydia trachomatis Using a Master Protocol.

Doernberg, Sarah B; Komarow, Lauren; Tran, Thuy Tien T; Sund, Zoe; Pandori, Mark W; Jensen, David; Tsalik, Ephraim L; ... (13 authors) (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020-12)

<h4>Background</h4>Pharyngeal and rectal Neisseria gonorrhoeae and Chlamydia trachomatis play important roles in infection and antibacterial resistance transmission, but no US Food and Drug Administration (FDA)-cleared assays ...