ALERT: This system is being upgraded on Tuesday December 12. It will not be available for use for several hours that day while the upgrade is in progress. Deposits to DukeSpace will be disabled on Monday December 11, so no new items are to be added to the repository while the upgrade is in progress. Everything should be back to normal by the end of day, December 12.

Now showing items 1-7 of 7

    • Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. 

      Liao, Hua-Xin; Lynch, Rebecca; Zhou, Tongqing; Gao, Feng; Alam, S Munir; Boyd, Scott D; Fire, Andrew Z; ... (45 authors) (Nature, 2013-04-25)
      Current human immunodeficiency virus-1 (HIV-1) vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise in approximately 20% of HIV-1-infected individuals, and details ...
    • Development of a contemporary globally diverse HIV viral panel by the EQAPOL program. 

      Sanchez, Ana M; DeMarco, C Todd; Hora, Bhavna; Keinonen, Sarah; Chen, Yue; Brinkley, Christie; Stone, Mars; ... (13 authors) (J Immunol Methods, 2014-07)
      The significant diversity among HIV-1 variants poses serious challenges for vaccine development and for developing sensitive assays for screening, surveillance, diagnosis, and clinical management. Recognizing a need to develop ...
    • Fast Dissemination of New HIV-1 CRF02/A1 Recombinants in Pakistan. 

      Chen, Yue; Hora, Bhavna; DeMarco, Todd; Shah, Sharaf Ali; Ahmed, Manzoor; Sanchez, Ana M; Su, Chang; ... (14 authors) (PLoS One, 2016)
      A number of HIV-1 subtypes are identified in Pakistan by characterization of partial viral gene sequences. Little is known whether new recombinants are generated and how they disseminate since whole genome sequences for ...
    • Genetic Characterization of a Panel of Diverse HIV-1 Isolates at Seven International Sites. 

      Hora, Bhavna; Keating, Sheila M; Chen, Yue; Sanchez, Ana M; Sabino, Ester; Hunt, Gillian; Ledwaba, Johanna; ... (21 authors) (PLoS One, 2016)
      HIV-1 subtypes and drug resistance are routinely tested by many international surveillance groups. However, results from different sites often vary. A systematic comparison of results from multiple sites is needed to determine ...
    • HIV-1 subtype C is significantly more infectious than other subtypes 

      Demarco, Todd; Rountree, Wes; Hora, Bhavna; Chen, Yue; Keinonen, Sarah; Racz, Laura; Daniell, Lily; ... (12 authors) (JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 2015-07)
    • Increased predominance of HIV-1 CRF01_AE and its recombinants in the Philippines. 

      Chen, Yue; Hora, Bhavna; DeMarco, Todd; Berba, Regina; Register, Heidi; Hood, Sylvia; Carter, Meredith; ... (13 authors) (The Journal of general virology, 2019-01-24)
      The growth rate of new HIV infections in the Philippines was the fastest of any countries in the Asia-Pacific region between 2010 and 2016. To date, HIV-1 subtyping results in the Philippines have been determined ...
    • Streamlined Subpopulation, Subtype, and Recombination Analysis of HIV-1 Half-Genome Sequences Generated by High-Throughput Sequencing. 

      Hora, Bhavna; Gulzar, Naila; Chen, Yue; Karagiannis, Konstantinos; Cai, Fangping; Su, Chang; Smith, Krista; ... (16 authors) (mSphere, 2020-10-14)
      High-throughput sequencing (HTS) has been widely used to characterize HIV-1 genome sequences. There are no algorithms currently that can directly determine genotype and quasispecies population using short HTS reads generated ...