Browsing by Author "Chiswell, Karen"
Now showing items 1-10 of 10
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A Decade On: Systematic Review of ClinicalTrials.gov Infectious Disease Trials, 2007-2017.
(Open forum infectious diseases, 2019-06)Background:Registration of interventional trials of Food and Drug Administration-regulated drug and biological products and devices became a legal requirement in 2007; the vast majority of these trials are registered in ... -
Compliance with results reporting at ClinicalTrials.gov.
(N Engl J Med, 2015-03-12)BACKGROUND: The Food and Drug Administration Amendments Act (FDAAA) mandates timely reporting of results of applicable clinical trials to ClinicalTrials.gov. We characterized the proportion of applicable clinical trials ... -
Pediatric Antibacterial and Antifungal Trials From 2007 to 2017.
(Pediatrics, 2018-09)BACKGROUND AND OBJECTIVES:The impact of the Best Pharmaceuticals for Children Act (BPCA) and the Pediatric Research Equity Act (PREA) on pediatric antibacterial or antifungal drug trials is unknown. Our objective was to ... -
Percutaneous coronary intervention outcomes in patients with stable coronary disease and left ventricular systolic dysfunction.
(ESC heart failure, 2019-12)AIMS:We sought to better understand the role of percutaneous coronary intervention (PCI) in patients with stable coronary artery disease (CAD) and moderate or severe left ventricular systolic dysfunction. METHODS ... -
Portfolio of clinical research in adult cardiovascular disease as reflected in ClinicalTrials.gov.
(Journal of the American Heart Association, 2013-09-26)Cardiovascular medicine is widely regarded as a vanguard for evidence-based drug and technology development. Our goal was to describe the cardiovascular clinical research portfolio from ClinicalTrials.gov.We identified 40 ... -
PROPHETIC: Prospective Identification of Pneumonia in Hospitalized Patients in the Intensive Care Unit.
(Chest, 2020-06-29)BACKGROUND:Pneumonia is the leading infection-related cause of death. Using simple clinical criteria and contemporary epidemiology to identify patients at high risk of nosocomial pneumonia should enhance prevention efforts ... -
Race and Sex Differences in QRS Interval and Associated Outcome Among Patients with Left Ventricular Systolic Dysfunction.
(J Am Heart Assoc, 2017-03-20)BACKGROUND: Prolonged QRS duration is associated with increased mortality among heart failure patients, but race or sex differences in QRS duration and associated effect on outcomes are unknown. METHODS AND RESULTS: ... -
Recent Clinical Trials in Osteoporosis: A Firm Foundation or Falling Short?
(PLoS One, 2016)The global burden of osteoporotic fractures is associated with significant morbidity, mortality, and healthcare costs. We examined the ClinicalTrials.gov database to determine whether recently registered clinical trials ... -
Relationship Between Cancer and Cardiovascular Outcomes Following Percutaneous Coronary Intervention.
(J Am Heart Assoc, 2015-07-06)BACKGROUND: Cardiovascular disease and cancer increasingly coexist, yet relationships between cancer and long-term cardiovascular outcomes post-percutaneous coronary intervention (PCI) are not well studied. METHODS AND RESULTS: ...
