Browsing by Author "Christensen, Kaare"
Now showing items 1-20 of 38
-
A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.
(J Gerontol A Biol Sci Med Sci, 2010-05)BACKGROUND: Genome-wide association studies (GWAS) may yield insights into longevity. METHODS: We performed a meta-analysis of GWAS in Caucasians from four prospective cohort studies: the Age, Gene/Environment Susceptibi... -
Age, gender, and cancer but not neurodegenerative and cardiovascular diseases strongly modulate systemic effect of the Apolipoprotein E4 allele on lifespan.
(PLoS Genet, 2014-01)Enduring interest in the Apolipoprotein E (ApoE) polymorphism is ensured by its evolutionary-driven uniqueness in humans and its prominent role in geriatrics and gerontology. We use large samples of longitudinally followed ... -
Biogenetic mechanisms predisposing to complex phenotypes in parents may function differently in their children.
(J Gerontol A Biol Sci Med Sci, 2013-07)This study focuses on the participants of the Long Life Family Study to elucidate whether biogenetic mechanisms underlying relationships among heritable complex phenotypes in parents function in the same way for the same ... -
Birth cohort differences in the prevalence of longevity-associated variants in APOE and FOXO3A in Danish long-lived individuals.
(Exp Gerontol, 2014-09)Gene variants found to associate with human longevity in one population rarely replicate in other populations. The lack of consistent findings may partly be explained by genetic heterogeneity among long-lived individuals ... -
Cancer and longevity--is there a trade-off? A study of cooccurrence in Danish twin pairs born 1900-1918.
(J Gerontol A Biol Sci Med Sci, 2012-05)BACKGROUND: Animal models and a few human studies have suggested a complex interaction between cancer risk and longevity indicating a trade-off where low cancer risk is associated with accelerating aging phenotypes and, ... -
Changes in hospitalisation and surgical procedures among the oldest-old: a follow-up study of the entire Danish 1895 and 1905 cohorts from ages 85 to 99 years.
(Age Ageing, 2013-07)OBJECTIVE: to examine whether the Danish 1905 cohort members had more active hospital treatment than the 1895 cohort members from ages 85 to 99 years and whether it results in higher in-hospital and post-operative mortality. ... -
Cross-national comparison of sex differences in health and mortality in Denmark, Japan and the US.
(Eur J Epidemiol, 2010-07)The present study aims to compare the direction and magnitude of sex differences in mortality and major health dimensions across Denmark, Japan and the US. The Human Mortality Database was used to examine sex differences ... -
DNA methylation age is associated with mortality in a longitudinal Danish twin study.
(Aging Cell, 2016-02)An epigenetic profile defining the DNA methylation age (DNAm age) of an individual has been suggested to be a biomarker of aging, and thus possibly providing a tool for assessment of health and mortality. In this study, ... -
Do gender, disability, and morbidity affect aging rate in the LLFS? Application of indices of cumulative deficits.
(Mech Ageing Dev, 2011-04)We used an approach of cumulative deficits to evaluate the rate of aging in 4954 participants of the Long-Life Family Study (LLFS) recruited in the U.S. (Boston, New York, and Pittsburgh) and Denmark. We used an array of ... -
Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.
(Age (Dordr), 2013-04)In this study, we investigated 102 single-nucleotide polymorphisms (SNPs) covering the common genetic variation in 16 genes recurrently regarded as candidates for human longevity: APOE; ACE; CETP; HFE; IL6; IL6R; MTHFR; ... -
Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study.
(Aging Cell, 2013-04)Clear evidence exists for heritability of human longevity, and much interest is focused on identifying genes associated with longer lives. To identify such longevity alleles, we performed the largest genome-wide linkage ... -
Health and function of participants in the Long Life Family Study: A comparison with other cohorts.
(Aging (Albany NY), 2011-01)Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559) were examined and compared to individuals from other cohorts to determine whether the recruitment targeting longevity resulted in a cohort ... -
Heritability estimates of endophenotypes of long and health life: the Long Life Family Study.
(J Gerontol A Biol Sci Med Sci, 2010-12)BACKGROUND: Identification of gene variants that contribute to exceptional survival may provide critical biologic information that informs optimal health across the life span. METHODS: As part of phenotype development efforts ... -
Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: cross sectional and longitudinal studies.
(Exp Gerontol, 2012-05)Here we explore association with human longevity of common genetic variation in three major candidate pathways: GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidants by investigating 1273 tagging ... -
Increased effect of the ApoE gene on survival at advanced age in healthy and long-lived Danes: two nationwide cohort studies.
(Aging Cell, 2010-12)Studies of Nordic twins suggest an increased genetic influence on mortality with age. Contrary to this, the heterogeneity hypothesis predicts that the mortality of individuals carrying a 'frail' or 'risky' genotype in a ... -
Influence of host genetics and environment on nasal carriage of staphylococcus aureus in danish middle-aged and elderly twins.
(J Infect Dis, 2012-10)BACKGROUND: Nasal carriage is a major risk factor for Staphylococcus aureus infection. Approximately, one-quarter of adults carry S. aureus. However, the role of host genetics on S. aureus nasal carriage is unknown. METHODS: ... -
Low tobacco-related cancer incidence in offspring of long-lived siblings: a comparison with Danish national cancer registry data.
(Ann Epidemiol, 2015-08)PURPOSE: Familial clustering of longevity is well documented and includes both genetic and other familial factors, but the specific underlying mechanisms are largely unknown. We examined whether low incidence of specific ... -
[More people live to be very old and with a better functioning].
(Ugeskr Laeger, 2013-10-07)Death rates for 80+-year-olds are now half of what they were after WWII. The chance of living past 90 years has gone up by roughly 30% per decade for people born in Denmark in 1895, 1905, and 1915 - and the later cohorts ... -
Novel loci and pathways significantly associated with longevity.
(Sci Rep, 2016-02-25)Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health ...
