Browsing by Author "Chung, Chang Y"
Now showing items 1-7 of 7
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Bimodal analysis reveals a general scaling law governing nondirected and chemotactic cell motility.
(Biophysical journal, 2010-07)Cell motility is a fundamental process with relevance to embryonic development, immune response, and metastasis. Cells move either spontaneously, in a nondirected fashion, or in response to chemotactic signals, in a directed ... -
Differential regulation of adhesion and phagocytosis of resting and activated microglia by dopamine
(Frontiers in Cellular Neuroscience, 2018-09-11)© 2018 Fan, Chen, Pathak, Carneiro and Chung. Microglia, the immune competent cells of the central nervous system (CNS), normally exist in a resting state characterized by a ramified morphology with many processes, and become ... -
Mefenamic acid can attenuate depressive symptoms by suppressing microglia activation induced upon chronic stress.
(Brain research, 2020-08)BACKGROUND:Depression is the most debilitating neuropsychiatric disorder, and psychosocial stressors are major risk factors for the onset of depression. Depression is closely associated with chronic inflammation and microglia ... -
Regulation of Integrin α6 Recycling by Calcium-independent Phospholipase A2 (iPLA2) to Promote Microglia Chemotaxis on Laminin.
(The Journal of biological chemistry, 2016-11)Microglia are the immune effector cells that are activated in response to pathological changes in the central nervous system. Microglial activation is accompanied by the alteration of integrin expression on the microglia ... -
Role of iPLA(2) in the regulation of Src trafficking and microglia chemotaxis.
(Traffic (Copenhagen, Denmark), 2011-07)Microglia are immune effector cells in the central nervous system (CNS) and their activation, migration and proliferation play crucial roles in brain injuries and diseases. We examined the role of intracellular ... -
Signaling Pathways Controlling Microglia Chemotaxis.
(Molecules and cells, 2017-03-17)Microglia are the primary resident immune cells of the central nervous system (CNS). They are the first line of defense of the brain's innate immune response against infection, injury, and diseases. Microglia respond to ... -
β-arrestin 2-dependent activation of ERK1/2 is required for ADP-induced paxillin phosphorylation at Ser(83) and microglia chemotaxis.
(Glia, 2012-09)Microglia play crucial roles in increased inflammation in the central nervous system upon brain injuries and diseases. Extracellular ADP has been reported to induce microglia chemotaxis and membrane ruffle formation through ...
