Now showing items 1-12 of 12

    • A translatable predictor of human radiation exposure. 

      Abedi, M; Chao, Nelson J; Chute, JP; Dressman, HK; Himburg, Heather; Lucas, J; Minor, K; ... (12 authors) (PLoS One, 2014)
      Terrorism using radiological dirty bombs or improvised nuclear devices is recognized as a major threat to both public health and national security. In the event of a radiological or nuclear disaster, rapid and accurate ...
    • Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration. 

      Chao, Nelson J; Chute, JP; Doan, Phuong Linh; Fang, T; Himburg, Heather; Kan, J; Pohl, K; ... (12 authors) (Cell Rep, 2016-11-01)
      Imprinted genes are differentially expressed by adult stem cells, but their functions in regulating adult stem cell fate are incompletely understood. Here we show that growth factor receptor-bound protein 10 (Grb10), an ...
    • Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles. 

      Chao, Nelson J; Chute, JP; Daher, P; Doan, Phuong Linh; Dressman, HK; Himburg, Heather; Lucas, J; ... (10 authors) (PLoS One, 2010-07-12)
      In the event of a terrorist-mediated attack in the United States using radiological or improvised nuclear weapons, it is expected that hundreds of thousands of people could be exposed to life-threatening levels of ionizing ...
    • Epidermal growth factor regulates hematopoietic regeneration after radiation injury. 

      Chao, Nelson J; Chute, JP; Deoliviera, D; Doan, Phuong Linh; Fixsen, Emma; Harris, Jeffrey R; Helms, K; ... (12 authors) (Nat Med, 2013-03)
      The mechanisms that regulate hematopoietic stem cell (HSC) regeneration after myelosuppressive injury are not well understood. We identified epidermal growth factor (EGF) to be highly enriched in the bone marrow serum of ...
    • Ex vivo expansion of murine and human hematopoietic stem cells 

      Doan, Phuong Linh; Chute, JP (Methods in Molecular Biology, 2014)
      Hematopoietic stem cells have the capacity to self-renew and give rise to the entirety of the mature blood and immune system throughout the lifespan of an organism. Here, we describe methods to isolate and culture murine ...
    • Ex vivo expansion of murine and human hematopoietic stem cells. 

      Doan, Phuong Linh; Chute, JP (Methods Mol Biol, 2014)
      Hematopoietic stem cells have the capacity to self-renew and give rise to the entirety of the mature blood and immune system throughout the lifespan of an organism. Here, we describe methods to isolate and culture murine ...
    • Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. 

      Chao, Nelson J; Chute, JP; Dressman, HK; Ginsburg, Geoffrey Steven; Himburg, Heather; Meadows, Sarah K; Muramoto, Garrett G; ... (10 authors) (PLoS One, 2008-04-02)
      BACKGROUND: Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. METHODS AND FINDINGS: We have sought to determine the ...
    • Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. 

      Chao, Nelson J; Chute, JP; Dressman, HK; Ginsburg, Geoffrey Steven; Himburg, Heather; Meadows, Sarah K; Muramoto, Garrett G; ... (10 authors) (PLoS One, 2008-04-02)
      BACKGROUND: Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. METHODS AND FINDINGS: We have sought to determine the ...
    • Gene expression signatures that predict radiation exposure in mice and humans. 

      Chao, Nelson J; Chute, JP; Dressman, HK; Ginsburg, Geoffrey Steven; Marshall, D; Meadows, Sarah K; Muramoto, Garrett G; ... (8 authors) (PLoS Med, 2007-04)
      BACKGROUND: The capacity to assess environmental inputs to biological phenotypes is limited by methods that can accurately and quantitatively measure these contributions. One such example can be seen in the context of exposure ...
    • Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. 

      Bourland, JD; Chao, Nelson J; Chen, BJ; Chute, JP; Cline, JM; Daher, P; Deoliveira, D; ... (16 authors) (PLoS One, 2010-06-16)
      Medications that can mitigate against radiation injury are limited. In this study, we investigated the ability of recombinant human growth hormone (rhGH) to mitigate against radiation injury in mice and nonhuman primates. ...
    • Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches. 

      Choi, SS; Chute, JP; Diehl, Anna Mae; Garman, Katherine S; Guy, Cynthia D; Himburg, Heather; Krüger, L; ... (16 authors) (Gut, 2016-04)
      OBJECTIVE: The ductular reaction (DR) involves mobilisation of reactive-appearing duct-like cells (RDC) along canals of Hering, and myofibroblastic (MF) differentiation of hepatic stellate cells (HSC) in the space of Disse. ...
    • Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity. 

      Chao, Nelson J; Chute, JP; Doan, Phuong Linh; Himburg, Heather; Nakamura, M; Quarmyne, M; Yan, X; ... (8 authors) (J Clin Invest, 2015-01)
      Hematopoietic stem cell (HSC) function is regulated by activation of receptor tyrosine kinases (RTKs). Receptor protein tyrosine phosphatases (PTPs) counterbalance RTK signaling; however, the functions of receptor PTPs in ...