Now showing items 1-3 of 3

    • Allosteric modulation of nucleoporin assemblies by intrinsically disordered regions. 

      Coutavas, Elias; Blus, Bartlomiej Jan; Koh, Junseock; Krolak, Aleksandra; Seo, Hyuk-Soo; Blobel, Günter (Science advances, 2019-11-27)
      Intrinsically disordered regions (IDRs) of proteins are implicated in key macromolecular interactions. However, the molecular forces underlying IDR function within multicomponent assemblies remain elusive. By combining ...
    • Günter Blobel: Pioneer of molecular cell biology (1936-2018). 

      Coutavas, Elias (The Journal of cell biology, 2018-04)
      Günter Blobel was a scientific colossus who dedicated his career to understanding the mechanisms for protein sorting to membrane organelles. His monumental contributions established research paradigms for major arenas of ...
    • Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments 

      Coutavas, Elias; Wang, Rong; Qi, Xiaofeng; Schmiege, Philip; Coutavas, Elias; Li, Xiaochun (Science Advances, 2020-02)
      <jats:p>Many cell surface receptors internalize their ligands and deliver them to endosomes, where the acidic pH causes the ligand to dissociate. The liberated receptor returns to the cell surface in a process called receptor ...