Browsing by Author "Cox, Nathan J"

Now showing items 1-3 of 3

    • A novel glycoproteomics workflow reveals dynamic O-GlcNAcylation of COPγ1 as a candidate regulator of protein trafficking 

      Cox, Nathan J; Luo, Peter M; Smith, Timothy J; Bisnett, Brittany J; Soderblom, Erik J; Boyce, Michael (Frontiers in Endocrinology, 2018-10-15)
      Copyright © 2018 Cox, Luo, Smith, Bisnett, Soderblom and Boyce. O-linked ß-N-acetylglucosamine (O-GlcNAc) is an abundant and essential intracellular form of protein glycosylation in animals and plants. In humans, dysregulation ...

    • Dynamic Glycosylation Governs the Vertebrate COPII Protein Trafficking Pathway. 

      Cox, Nathan J; Unlu, Gokhan; Bisnett, Brittany J; Meister, Thomas R; Condon, Brett M; Luo, Peter M; Smith, Timothy J; ... (13 authors) (Biochemistry, 2018-01)
      The COPII coat complex, which mediates secretory cargo trafficking from the endoplasmic reticulum, is a key control point for subcellular protein targeting. Because misdirected proteins cannot function, protein sorting by ...

    • Structural basis of O-GlcNAc recognition by mammalian 14-3-3 proteins. 

      Toleman, Clifford A; Schumacher, Maria A; Yu, Seok-Ho; Zeng, Wenjie; Cox, Nathan J; Smith, Timothy J; Soderblom, Erik J; ... (10 authors) (Proceedings of the National Academy of Sciences of the United States of America, 2018-06)
      O-GlcNAc is an intracellular posttranslational modification that governs myriad cell biological processes and is dysregulated in human diseases. Despite this broad pathophysiological significance, the biochemical effects ...