Browsing by Author "Coyne, Carolyn B"
Now showing items 1-20 of 25
-
A Three-Dimensional Cell Culture Model To Study Enterovirus Infection of Polarized Intestinal Epithelial Cells.
(mSphere, 2016-01)Despite serving as the primary entry portal for coxsackievirus B (CVB), little is known about CVB infection of the intestinal epithelium, owing at least in part to the lack of suitable in vivo models and the inability of ... -
A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance.
(Science advances, 2016-03-04)In eutherians, the placenta acts as a barrier and conduit at the maternal-fetal interface. Syncytiotrophoblasts, the multinucleated cells that cover the placental villous tree surfaces of the human placenta, are directly ... -
ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry.
(PLoS pathogens, 2015-09-15)Interferon stimulated genes (ISGs) target viruses at various stages of their infectious life cycles, including at the earliest stage of viral entry. Here we identify ArfGAP with dual pleckstrin homology (PH) domains 2 (ADAP2) ... -
An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis.
(Cell host & microbe, 2020-03)Alphaviruses are emerging, mosquito-transmitted RNA viruses with poorly understood cellular tropism and species selectivity. Mxra8 is a receptor for multiple alphaviruses including chikungunya virus (CHIKV). We discovered ... -
BPIFB3 regulates autophagy and coxsackievirus B replication through a noncanonical pathway independent of the core initiation machinery.
(mBio, 2014-12-09)<h4>Unlabelled</h4>Enteroviruses require autophagy to facilitate the formation of autophagosome (AP)-like double-membrane vesicles that provide the scaffolding for RNA replication. Here, we identify bactericidal/permeabi... -
Catch me if you can: the link between autophagy and viruses.
(PLoS pathogens, 2015-03-26) -
Chromosome 19 microRNAs exert antiviral activity independent from type III interferon signaling.
(Placenta, 2018-01)INTRODUCTION:Cultured primary human trophoblasts (PHT), derived from term placentas, are relatively resistant to infection by diverse viruses. The resistance can be conferred to non-trophoblastic cells by pre-exposing them ... -
Cross-Reactive Dengue Virus Antibodies Augment Zika Virus Infection of Human Placental Macrophages.
(Cell host & microbe, 2018-11)Zika virus (ZIKV), which emerged in regions endemic to dengue virus (DENV), is vertically transmitted and results in adverse pregnancy outcomes. Antibodies to DENV can cross-react with ZIKV, but whether these antibodies ... -
Emerging arboviruses and implications for pediatric transplantation: A review.
(Pediatric transplantation, 2019-02)Recent years have brought a rise in newly emergent viral infections, primarily in the form of previously known arthropod-transmitted viruses that have increased significantly in both incidence and geographical range. Of ... -
Enteroviruses: A Gut-Wrenching Game of Entry, Detection, and Evasion.
(Viruses, 2019-05-21)Enteroviruses are a major source of human disease, particularly in neonates and young children where infections can range from acute, self-limited febrile illness to meningitis, endocarditis, hepatitis, and acute flaccid ... -
Gatekeepers of the fetus: Characterization of placental macrophages.
(The Journal of experimental medicine, 2021-01)In this issue of JEM, Thomas et al. (https://doi.org/10.1084/jem.20200891) provide elegant technological and conceptual advances that further our understanding of the immune cells enriched at the maternal-fetal interface. ... -
Gestational Stage and IFN-λ Signaling Regulate ZIKV Infection In Utero.
(Cell host & microbe, 2017-09)Although Zika virus (ZIKV)-induced congenital disease occurs more frequently during early stages of pregnancy, its basis remains undefined. Using established type I interferon (IFN)-deficient mouse models of ZIKV transmission ... -
Horsepox: Framing a dual use research of concern debate.
(PLoS pathogens, 2018-10-04) -
Imaging-Based Reporter Systems to Define CVB-Induced Membrane Remodeling in Living Cells.
(Viruses, 2020-09-25)Enteroviruses manipulate host membranes to form replication organelles, which concentrate viral and host factors to allow for efficient replication. However, this process has not been well-studied in living cells throughout ... -
Inflammasome signaling in human placental trophoblasts regulates immune defense against Listeria monocytogenes infection.
(The Journal of experimental medicine, 2021-01)The human placenta is a dynamic organ that modulates physiological adaptations to pregnancy. To define the immunological signature of the human placenta, we performed unbiased profiling of secreted immune factors from human ... -
Inhibiting Ebola virus and SARS-CoV-2 entry.
(Science (New York, N.Y.), 2020-10) -
PAMPs and DAMPs: signal 0s that spur autophagy and immunity.
(Immunological reviews, 2012-09)Pathogen-associated molecular pattern molecules (PAMPs) are derived from microorganisms and recognized by pattern recognition receptor (PRR)-bearing cells of the innate immune system as well as many epithelial cells. In ... -
RIPK3: Beyond Necroptosis.
(Immunity, 2019-01)In this issue of Immunity, Daniels et al. (2019) demonstrate that RIPK3 signaling limits Zika virus (ZIKV) infection in the central nervous system independently of its function in necroptosis by promoting itaconate production ... -
Stem Cell-Derived Models of Viral Infections in the Gastrointestinal Tract.
(Viruses, 2018-03-10)Studies on the intestinal epithelial response to viral infection have previously been limited by the absence of in vitro human intestinal models that recapitulate the multicellular complexity of the gastrointestinal tract. ... -
STING'ing Zika virus in neurons.
(Nature microbiology, 2018-09)Studies in Drosophila reveal that the insect homologue of the stimulator of interferon genes (STING) exerts antiviral activity against Zika virus infection in the fly brain through the induction of autophagy, providing key ...
