Now showing items 1-4 of 4

    • Assessment of LD matrix measures for the analysis of biological pathway association. 

      Crosslin, David R; Qin, Xuejun; Hauser, Elizabeth R (Stat Appl Genet Mol Biol, 2010)
      Complex diseases will have multiple functional sites, and it will be invaluable to understand the cross-locus interaction in terms of linkage disequilibrium (LD) between those sites (epistasis) in addition to the haplotype-LD ...
    • Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events. 

      Shah, Svati H; Bain, James R; Muehlbauer, Michael J; Stevens, Robert D; Crosslin, David R; Haynes, Carol; Dungan, Jennifer; ... (12 authors) (Circ Cardiovasc Genet, 2010-04)
      BACKGROUND: Molecular tools may provide insight into cardiovascular risk. We assessed whether metabolites discriminate coronary artery disease (CAD) and predict risk of cardiovascular events. METHODS AND RESULTS: We performed ...
    • Detectable clonal mosaicism from birth to old age and its relationship to cancer. 

      Laurie, Cathy C; Laurie, Cecelia A; Rice, Kenneth; Doheny, Kimberly F; Zelnick, Leila R; McHugh, Caitlin P; Ling, Hua; ... (73 authors) (Nature genetics, 2012-05-06)
      We detected clonal mosaicism for large chromosomal anomalies (duplications, deletions and uniparental disomy) using SNP microarray data from over 50,000 subjects recruited for genome-wide association studies. This detection ...
    • Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis. 

      Shah, Svati H; Freedman, Neil J; Zhang, Lisheng; Crosslin, David R; Stone, David H; Haynes, Carol; Johnson, Jessica; ... (22 authors) (PLoS Genet, 2009-01)
      Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD). We have previously identified genetic linkage to familial CAD in the genomic region of NPY. We performed follow-up genetic, biostatistical, ...