Browsing by Author "Dewhirst, MW"

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  • Kurokawa, M; Kim, J; Geradts, J; Matsuura, K; Liu, L; Ran, X; Xia, W; Ribar, TJ; Henao, R; Dewhirst, MW; Kim, WJ; Lucas, JE; Wang, S; Spector, NL; Kornbluth, S (2013-05-07)
    In the intrinsic pathway of apoptosis, cell-damaging signals promote the release of cytochrome c from mitochondria, triggering activation of the Apaf-1 and caspase-9 apoptosome. The ubiquitin E3 ligase MDM2 decreases the ...
  • Glass, Oliver Kent; Bowie, Michelle; Fuller, Julie; Darr, D; Usary, J; Boss, K; Choudhury, KR; Liu, X; Zhang, Z; Locasale, JW; Williams, C; Dewhirst, MW; Jones, LW; Seewaldt, V (2017-01-01)
    © Glass et al. Exposure to exercise following a breast cancer diagnosis is associated with reductions in the risk of recurrence. However, it is not known whether breast cancers within the same molecular-intrinsic subtype ...
  • Betof, AS; Lascola, CD; Weitzel, D; Landon, C; Scarbrough, PM; Devi, GR; Palmer, G; Jones, LW; Dewhirst, MW (2015-05)
    Exercise has been shown to improve postischemia perfusion of normal tissues; we investigated whether these effects extend to solid tumors. Estrogen receptor-negative (ER-, 4T1) and ER+ (E0771) tumor cells were implanted ...
  • Terman, DS; Viglianti, BL; Zennadi, R; Fels, D; Boruta, RJ; Yuan, H; Dreher, MR; Grant, G; Rabbani, ZN; Moon, E; Lan, L; Eble, J; Cao, Y; Sorg, B; Ashcraft, K; Palmer, G; Telen, MJ; Dewhirst, MW (2013)
    Resistance of hypoxic solid tumor niches to chemotherapy and radiotherapy remains a major scientific challenge that calls for conceptually new approaches. Here we exploit a hitherto unrecognized ability of sickled erythrocytes ...
  • Kersey, FR; Zhang, G; Palmer, GM; Dewhirst, MW; Fraser, CL (2010-09-28)
    Responsive biomaterials play important roles in imaging, diagnostics, and therapeutics. Polymeric nanoparticles (NPs) containing hydrophobic and hydrophilic segments are one class of biomaterial utilized for these purposes. ...
  • Oldham, Mark; Yoon, Paul; Fathi, Z; Beyer, WF; Adamson, Justus D; Liu, Leihua; Alcorta, D; Xia, W; Osada, T; Liu, Cong-Xiao; Yang, XY; Dodd, RD; Herndon, James E.; Meng, B; Kirsch, DG; Lyerly, HK; Dewhirst, MW; Fecci, Peter Edward; Walder, H; Spector, NL (2016)
    This work investigates X-PACT (X-ray Psoralen Activated Cancer Therapy): a new approach for the treatment of solid cancer. X-PACT utilizes psoralen, a potent anti-cancer therapeutic with current application to proliferative ...