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Browsing by Author "Eapen, Mary"
Now showing items 1-17 of 17
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Allele-level HLA matching for umbilical cord blood transplantation for non-malignant diseases in children: a retrospective analysis.
(The Lancet. Haematology, 2017-07)<h4>Background</h4>The standard for selecting unrelated umbilical cord blood units for transplantation for non-malignant diseases relies on antigen-level (lower resolution) HLA typing for HLA-A and HLA-B, and allele-level ... -
Analysis of risk factors influencing outcomes after cord blood transplantation in children with juvenile myelomonocytic leukemia: a EUROCORD, EBMT, EWOG-MDS, CIBMTR study.
(Blood, 2013-09)We retrospectively analyzed 110 patients with juvenile myelomonocytic leukemia, given single-unit, unrelated donor umbilical cord blood transplantation. Median age at diagnosis and at transplantation was 1.4 years (age range, ... -
Effect of cord blood processing on transplantation outcomes after single myeloablative umbilical cord blood transplantation.
(Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2015-04)Variations in cord blood manufacturing and administration are common, and the optimal practice is not known. We compared processing and banking practices at 16 public cord blood banks (CBB) in the United States and assessed ... -
Effect of HLA-matching recipients to donor noninherited maternal antigens on outcomes after mismatched umbilical cord blood transplantation for hematologic malignancy.
(Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2012-12)Transplantation-related mortality (TRM) is high after HLA-mismatched umbilical cord blood (UCB) transplantation (UCBT). In utero, exposure to noninherited maternal antigen (NIMA) is recognized by the fetus, which induces ... -
Long-term survival and late deaths after hematopoietic cell transplantation for primary immunodeficiency diseases and inborn errors of metabolism.
(Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2012-09)It is uncertain whether late mortality rates after hematopoietic cell transplantation for severe combined immunodeficiency (SCID), non-SCID primary immunodeficiency diseases (non-SCID PIDD), and inborn errors of metabolism ... -
Myelodysplastic syndrome evolving from aplastic anemia treated with immunosuppressive therapy: efficacy of hematopoietic stem cell transplantation.
(Haematologica, 2014-12)A proportion of patients with aplastic anemia who are treated with immunosuppressive therapy develop clonal hematologic disorders, including post-aplastic anemia myelodysplastic syndrome. Many will proceed to allogeneic ... -
One-unit versus two-unit cord-blood transplantation for hematologic cancers.
(The New England journal of medicine, 2014-10)<h4>Background</h4>Umbilical-cord blood has been used as the source of hematopoietic stem cells in an estimated 30,000 transplants. The limited number of hematopoietic cells in a single cord-blood unit prevents its use in ... -
One-unit versus two-unit cord-blood transplantation.
(The New England journal of medicine, 2015-01) -
Outcome of Hematopoietic Cell Transplantation for DNA-Double Strand Breakage Repair Disorders.
(J Allergy Clin Immunol, 2017-04-06)BACKGROUND: Rare DNA breakage-repair disorders predispose to infection and lympho-reticular malignancies. Hematopoietic cell transplantation (HCT) is curative but co-administered chemo- or radio-therapy is damaging due to ... -
Outcome of transplantation for acute lymphoblastic leukemia in children with Down syndrome.
(Pediatric blood & cancer, 2014-06)We report on 27 patients with Down syndrome (DS) and acute lymphoblastic leukemia (ALL) who received allogeneic hematopoietic cell transplantation (HCT) between 2000 and 2009. Seventy-eight percent of patients received ... -
Outcome of transplantation for acute myelogenous leukemia in children with Down syndrome.
(Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2013-06)Data on outcomes of allogeneic transplantation in children with Down syndrome and acute myelogenous leukemia (DS-AML) are scarce and conflicting. Early reports stress treatment-related mortality as the main barrier; a recent ... -
Outcomes after hematopoietic stem cell transplantation for children with I-cell disease.
(Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2014-11)Mucolipidosis type II (MLII), or I-cell disease, is a rare but severe disorder affecting localization of enzymes to the lysosome, generally resulting in death before the 10th birthday. Although hematopoietic stem ... -
Outcomes of allogeneic hematopoietic cell transplantation in patients with dyskeratosis congenita.
(Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2013-08)We describe outcomes after allogeneic transplantation in 34 patients with dyskeratosis congenita who underwent transplantation between 1981 and 2009. The median age at transplantation was 13 years (range, 2 to 35). Approximately ... -
Outcomes of transplantation using various hematopoietic cell sources in children with Hurler syndrome after myeloablative conditioning.
(Blood, 2013-05)We report transplantation outcomes of 258 children with Hurler syndrome (HS) after a myeloablative conditioning regimen from 1995 to 2007. Median age at transplant was 16.7 months and median follow-up was 57 months. The ... -
Sickle cell disease: an international survey of results of HLA-identical sibling hematopoietic stem cell transplantation.
(Blood, 2017-03)Despite advances in supportive therapy to prevent complications of sickle cell disease (SCD), access to care is not universal. Hematopoietic cell transplantation is, to date, the only curative therapy for SCD, but its application ... -
Umbilical cord blood transplantation for children with thalassemia and sickle cell disease.
(Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2011-09)We examined the efficacy of unrelated cord blood (CB) transplantation in children with thalassemia (n = 35) and sickle cell disease (n = 16), using data reported to 3 registries. Donor-recipient pairs were matched at HLA-A ... -
Umbilical Cord Blood Transplantation in Children with Acute Leukemia: Impact of Conditioning on Transplantation Outcomes.
(Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2017-10)The Blood and Marrow Transplant Clinical Trials Network (BMT CTN 0501) randomized children with hematologic malignancies to transplantation with 1 or 2 cord blood units (UCB) between 2006 and 2012. While the trial concluded ...
