Now showing items 1-6 of 6

    • Common genetic variation and the control of HIV-1 in humans. 

      Antonarakis, SE; Beckmann, JS; Carrington, Mary; Castagna, A; Cirulli Rogers, Elizabeth T; Colombo, S; Cozzi-Lepri, A; ... (38 authors) (PLoS Genet, 2009-12)
      To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants ...
    • Genome-wide mRNA expression correlates of viral control in CD4+ T-cells from HIV-1-infected individuals. 

      Center for HIV/AIDS Vaccine Immunology; Dang, KK; Descombes, P; Fellay, J; Feng, S; Ge, Dongliang; Goldstein, David Benjamin; ... (13 authors) (PLoS Pathog, 2010-02-26)
      There is great interindividual variability in HIV-1 viral setpoint after seroconversion, some of which is known to be due to genetic differences among infected individuals. Here, our focus is on determining, genome-wide, ...
    • Host determinants of HIV-1 control in African Americans. 

      Carrington, Mary; Cronin, KD; Fellay, J; Gao, X; Ge, Dongliang; Goldstein, David Benjamin; Gumbs, Curtis E; ... (16 authors) (J Infect Dis, 2010-04-15)
      We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene ...
    • Host genetics and HIV-1: the final phase? 

      Fellay, J; Goldstein, David Benjamin; Shianna, Kevin V; Telenti, A (PLoS Pathog, 2010-10-14)
      This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been published ...
    • Influence of HLA-C expression level on HIV control. 

      Apps, R; Bosch, R; Brumme, CJ; Brumme, ZL; Buchbinder, S; Carlson, JM; Carrington, Mary; ... (37 authors) (Science, 2013-04-05)
      A variant upstream of human leukocyte antigen C (HLA-C) shows the most significant genome-wide effect on HIV control in European Americans and is also associated with the level of HLA-C expression. We characterized ...
    • The characterization of twenty sequenced human genomes. 

      Campbell, CR; Cirulli Rogers, Elizabeth T; Dickson, SP; Fellay, J; Ge, Dongliang; Goedert, JJ; Goldstein, David Benjamin; ... (25 authors) (PLoS Genet, 2010-09-09)
      We present the analysis of twenty human genomes to evaluate the prospects for identifying rare functional variants that contribute to a phenotype of interest. We sequenced at high coverage ten "case" genomes from individuals ...