Now showing items 1-20 of 26

    • A polyaxonal amacrine cell population in the primate retina. 

      Greschner, Martin; Field, Greg D; Li, Peter H; Schiff, Max L; Gauthier, Jeffrey L; Ahn, Daniel; Sher, Alexander; ... (9 authors) (The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014-03)
      Amacrine cells are the most diverse and least understood cell class in the retina. Polyaxonal amacrine cells (PACs) are a unique subset identified by multiple long axonal processes. To explore their functional properties, ...
    • Activation of Rod Input in a Model of Retinal Degeneration Reverses Retinal Remodeling and Induces Formation of Functional Synapses and Recovery of Visual Signaling in the Adult Retina. 

      Wang, Tian; Pahlberg, Johan; Cafaro, Jon; Frederiksen, Rikard; Cooper, AJ; Sampath, Alapakkam P; Field, Greg D; ... (8 authors) (The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019-08)
      A major cause of human blindness is the death of rod photoreceptors. As rods degenerate, synaptic structures between rod and rod bipolar cells disappear and the rod bipolar cells extend their dendrites and occasionally make ...
    • Advances in Color Science: From Retina to Behavior (vol 30, pg 14955, 2010) 

      Conway, Bevil R; Chatterjee, Soumya; Field, Greg D; Horwitz, Gregory D; Johnson, Elizabeth N; Koida, Kowa; Mancuso, Katherine (JOURNAL OF NEUROSCIENCE, 2010-12-08)
    • Advances in color science: from retina to behavior. 

      Conway, Bevil R; Chatterjee, Soumya; Field, Greg D; Horwitz, Gregory D; Johnson, Elizabeth N; Koida, Kowa; Mancuso, Katherine (The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010-11)
      Color has become a premier model system for understanding how information is processed by neural circuits, and for investigating the relationships among genes, neural circuits, and perception. Both the physical stimulus ...
    • Anatomical identification of extracellularly recorded cells in large-scale multielectrode recordings. 

      Li, Peter H; Gauthier, Jeffrey L; Schiff, Max; Sher, Alexander; Ahn, Daniel; Field, Greg D; Greschner, Martin; ... (10 authors) (J Neurosci, 2015-03-18)
      This study combines for the first time two major approaches to understanding the function and structure of neural circuits: large-scale multielectrode recordings, and confocal imaging of labeled neurons. To achieve this ...
    • Behavioural and physiological limits to vision in mammals. 

      Field, Greg D; Sampath, Alapakkam P (Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2017-04)
      Human vision is exquisitely sensitive-a dark-adapted observer is capable of reliably detecting the absorption of a few quanta of light. Such sensitivity requires that the sensory receptors of the retina, rod photoreceptors, ...
    • Cell type-specific changes in retinal ganglion cell function induced by rod death and cone reorganization in rats. 

      Yu, Wan-Qing; Grzywacz, Norberto M; Lee, Eun-Jin; Field, Greg D (Journal of neurophysiology, 2017-07)
      We have determined the impact of rod death and cone reorganization on the spatiotemporal receptive fields (RFs) and spontaneous activity of distinct retinal ganglion cell (RGC) types. We compared RGC function between healthy ...
    • Correlated firing among major ganglion cell types in primate retina. 

      Greschner, Martin; Shlens, Jonathon; Bakolitsa, Constantina; Field, Greg D; Gauthier, Jeffrey L; Jepson, Lauren H; Sher, Alexander; ... (9 authors) (The Journal of physiology, 2011-01)
      Retinal ganglion cells exhibit substantial correlated firing: a tendency to fire nearly synchronously at rates different from those expected by chance. These correlations suggest that network interactions significantly shape ...
    • Distribution and diversity of intrinsically photosensitive retinal ganglion cells in tree shrew. 

      Johnson, Elizabeth N; Westbrook, Teleza; Shayesteh, Rod; Chen, Emily L; Schumacher, Joseph W; Fitzpatrick, David; Field, Greg D (The Journal of comparative neurology, 2017-12-14)
      Intrinsically photosensitive retinal ganglion cells (ipRGCs) mediate the pupillary light reflex, circadian entrainment, and may contribute to luminance and color perception. The diversity of ipRGCs varies from rodents to ...
    • Dopaminergic modulation of retinal processing from starlight to sunlight. 

      Roy, Suva; Field, Greg D (Journal of pharmacological sciences, 2019-05-04)
      Neuromodulators such as dopamine, enable context-dependent plasticity of neural circuit function throughout the central nervous system. For example, in the retina, dopamine tunes visual processing for daylight and nightlight ...
    • Efficient coding of spatial information in the primate retina. 

      Doi, Eizaburo; Gauthier, Jeffrey L; Field, Greg D; Shlens, Jonathon; Sher, Alexander; Greschner, Martin; Machado, Timothy A; ... (14 authors) (The Journal of neuroscience : the official journal of the Society for Neuroscience, 2012-11)
      Sensory neurons have been hypothesized to efficiently encode signals from the natural environment subject to resource constraints. The predictions of this efficient coding hypothesis regarding the spatial filtering properties ...
    • Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact. 

      Ray, Thomas A; Roy, Suva; Kozlowski, Christopher; Wang, Jingjing; Cafaro, Jon; Hulbert, Samuel W; Wright, Christopher V; ... (9 authors) (eLife, 2018-04-03)
      A common strategy by which developing neurons locate their synaptic partners is through projections to circuit-specific neuropil sublayers. Once established, sublayers serve as a substrate for selective synapse formation, ...
    • Functional connectivity in the retina at the resolution of photoreceptors. 

      Field, Greg D; Gauthier, Jeffrey L; Sher, Alexander; Greschner, Martin; Machado, Timothy A; Jepson, Lauren H; Shlens, Jonathon; ... (13 authors) (Nature, 2010-10)
      To understand a neural circuit requires knowledge of its connectivity. Here we report measurements of functional connectivity between the input and ouput layers of the macaque retina at single-cell resolution and the implications ...
    • Gap Junctions Contribute to Differential Light Adaptation across Direction-Selective Retinal Ganglion Cells. 

      Yao, Xiaoyang; Cafaro, Jon; McLaughlin, Amanda J; Postma, Friso R; Paul, David L; Awatramani, Gautam; Field, Greg D (Neuron, 2018-10)
      Direction-selective ganglion cells (DSGCs) deliver signals from the retina to multiple brain areas to indicate the presence and direction of motion. Delivering reliable signals in response to motion is critical across light ...
    • Global Motion Processing by Populations of Direction-Selective Retinal Ganglion Cells. 

      Cafaro, Jon; Zylberberg, Joel; Field, Greg D (The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020-07)
      Simple stimuli have been critical to understanding neural population codes in sensory systems. Yet it remains necessary to determine the extent to which this understanding generalizes to more complex conditions. To examine ...
    • High-sensitivity rod photoreceptor input to the blue-yellow color opponent pathway in macaque retina. 

      Field, Greg D; Greschner, Martin; Gauthier, Jeffrey L; Rangel, Carolina; Shlens, Jonathon; Sher, Alexander; Marshak, David W; ... (9 authors) (Nat Neurosci, 2009-09)
      Small bistratified cells (SBCs) in the primate retina carry a major blue-yellow opponent signal to the brain. We found that SBCs also carry signals from rod photoreceptors, with the same sign as S cone input. SBCs exhibited ...
    • Identification of a Retinal Circuit for Recurrent Suppression Using Indirect Electrical Imaging. 

      Greschner, Martin; Heitman, Alexander K; Field, Greg D; Li, Peter H; Ahn, Daniel; Sher, Alexander; Litke, Alan M; ... (8 authors) (Current biology : CB, 2016-08)
      Understanding the function of modulatory interneuron networks is a major challenge, because such networks typically operate over long spatial scales and involve many neurons of different types. Here, we use an indirect electrical ...
    • Ignoring correlated activity causes a failure of retinal population codes. 

      Ruda, Kiersten; Zylberberg, Joel; Field, Greg D (Nature communications, 2020-09-14)
      From starlight to sunlight, adaptation alters retinal output, changing both the signal and noise among populations of retinal ganglion cells (RGCs). Here we determine how these light level-dependent changes impact decoding ...
    • Mapping nonlinear receptive field structure in primate retina at single cone resolution. 

      Freeman, Jeremy; Field, Greg D; Li, Peter H; Greschner, Martin; Gunning, Deborah E; Mathieson, Keith; Sher, Alexander; ... (11 authors) (eLife, 2015-10-30)
      The function of a neural circuit is shaped by the computations performed by its interneurons, which in many cases are not easily accessible to experimental investigation. Here, we elucidate the transformation of visual signals ...
    • Nogo receptor 1 is expressed by nearly all retinal ganglion cells. 

      Solomon, Alexander M; Westbrook, Teleza; Field, Greg D; McGee, Aaron W (PloS one, 2018-01)
      A variety of conditions ranging from glaucoma to blunt force trauma lead to optic nerve atrophy. Identifying signaling pathways for stimulating axon growth in the optic nerve may lead to treatments for these pathologies. ...