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Browsing by Author "Fire, Andrew Z"

Now showing items 1-2 of 2

    • Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. 

      Liao, Hua-Xin; Lynch, Rebecca; Zhou, Tongqing; Gao, Feng; Alam, S Munir; Boyd, Scott D; Fire, Andrew Z; ... (45 authors) (Nature, 2013-04-25)
      Current human immunodeficiency virus-1 (HIV-1) vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise in approximately 20% of HIV-1-infected individuals, and details ...

    • Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated. 

      Liao, Hua-Xin; Chen, Xi; Munshaw, Supriya; Zhang, Ruijun; Marshall, Dawn J; Vandergrift, Nathan; Whitesides, John F; ... (32 authors) (J Exp Med, 2011-10-24)
      The initial antibody response to HIV-1 is targeted to envelope (Env) gp41, and is nonneutralizing and ineffective in controlling viremia. To understand the origins and characteristics of gp41-binding antibodies produced ...