Browsing by Author "Floyd, Scott R"
Now showing items 1-10 of 10
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B7-H3-redirected chimeric antigen receptor T cells target glioblastoma and neurospheres.
(EBioMedicine, 2019-09)<h4>Background</h4>The dismal survival of glioblastoma (GBM) patients urgently calls for the development of new treatments. Chimeric antigen receptor T (CAR-T) cells are an attractive strategy, but preclinical and clinical ... -
BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation.
(Cell reports, 2020-09)Effective spatio-temporal control of transcription and replication during S-phase is paramount to maintaining genomic integrity and cell survival. Dysregulation of these systems can lead to conflicts between the transcription ... -
CometChip enables parallel analysis of multiple DNA repair activities.
(DNA repair, 2021-10)DNA damage can be cytotoxic and mutagenic, and it is directly linked to aging, cancer, and other diseases. To counteract the deleterious effects of DNA damage, cells have evolved highly conserved DNA repair pathways. Many ... -
Dosimetric analysis of the alopecia preventing effect of hippocampus sparing whole brain radiation therapy.
(Radiat Oncol, 2015-11-26)BACKGROUND: Whole brain radiation therapy (WBRT) is widely used for the treatment of brain metastases. Cognitive decline and alopecia are recognized adverse effects of WBRT. Recently hippocampus sparing whole brain radiation ... -
Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles.
(Nature communications, 2018-05-18)Effective treatment for glioblastoma (GBM) is limited by the presence of the blood-brain barrier (BBB) and rapid resistance to single agent therapies. To address these issues, we developed a transferrin-functionalized ... -
Fostering Radiation Oncology Physician Scientist Trainees Within a Diverse Workforce: The Radiation Oncology Research Scholar Track.
(International journal of radiation oncology, biology, physics, 2021-06)There is a need to foster future generations of radiation oncology physician scientists, but the number of radiation oncologists with sufficient education, training, and funding to make transformative discoveries is relatively ... -
Ipilmumab and cranial radiation in metastatic melanoma patients: a case series and review.
(J Immunother Cancer, 2015)BACKGROUND: Ipilimumab improves survival in metastatic melanoma patients. This population frequently develops brain metastases, which have been associated with poor survival and are often treated with radiation. Therefore, ... -
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.
(Nature, 2013-06-13)DNA damage activates a signalling network that blocks cell-cycle progression, recruits DNA repair factors and/or triggers senescence or programmed cell death. Alterations in chromatin structure are implicated in the initiation ... -
The effect of MLC leaf width in single-isocenter multi-target radiosurgery with volumetric modulated arc therapy
(Journal of Radiosurgery and SBRT, 2019-01-01)© 2019 Old City Publishing, Inc. Purpose: Single-isocenter multi-target (SIMT) volumetric modulated arc therapy (VMAT) is primarily limited to linear accelerators utilizing 2.5 mm leaf width MLCs. We explore feasibility ... -
The role of whole brain radiation therapy in the management of melanoma brain metastases.
(Radiat Oncol, 2014-06-22)BACKGROUND: Brain metastases are common in patients with melanoma, and optimal management is not well defined. As melanoma has traditionally been thought of as "radioresistant," the role of whole brain radiation therapy ...
