Browsing by Author "Fowler, Vance G"
Now showing items 1-20 of 62
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A genome-wide association study of variants associated with acquisition of Staphylococcus aureus bacteremia in a healthcare setting.
(BMC Infect Dis, 2014-02-13)BACKGROUND: Humans vary in their susceptibility to acquiring Staphylococcus aureus infection, and research suggests that there is a genetic basis for this variability. Several recent genome-wide association studies (GWAS) ... -
A randomized Phase 2 trial of telavancin versus standard therapy in patients with uncomplicated Staphylococcus aureus bacteremia: the ASSURE study.
(BMC Infect Dis, 2014-05-23)BACKGROUND: Staphylococcus aureus bacteremia is a common infection associated with significant morbidity and mortality. Telavancin is a bactericidal lipoglycopeptide active against Gram-positive pathogens, including ... -
An integrated transcriptome and expressed variant analysis of sepsis survival and death.
(Genome Med, 2014)BACKGROUND: Sepsis, a leading cause of morbidity and mortality, is not a homogeneous disease but rather a syndrome encompassing many heterogeneous pathophysiologies. Patient factors including genetics predispose to poor ... -
Analysis of the Impact of Early Surgery on In-Hospital Mortality of Native Valve Endocarditis
(2010-03)Background— The impact of early surgery on mortality in patients with native valve endocarditis (NVE) is unresolved. This study sought to evaluate valve surgery compared with medical therapy for NVE and to identify ... -
Analytical Evaluation of the Abbott RealTime CT/NG Assay for Detection of Chlamydia trachomatis and Neisseria gonorrhoeae in Rectal and Pharyngeal Swabs.
(The Journal of molecular diagnostics : JMD, 2020-06)Chlamydia trachomatis and Neisseria gonorrhoeae infections in the rectum and pharynx are important extragenital reservoirs of infection. Few assays approved by the US Food and Drug Administration are commercially available ... -
Antibacterial Resistance Leadership Group 2.0: Back to Business.
(Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021-08)In December 2019, the Antibacterial Resistance Leadership Group (ARLG) was awarded funding for another 7-year cycle to support a clinical research network on antibacterial resistance. ARLG 2.0 has 3 overarching research ... -
Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease.
(Open Forum Infect Dis, 2016-01)Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with ... -
Bacteremia in solid organ transplant recipients as compared to immunocompetent patients: Acute phase cytokines and outcomes in a prospective, matched cohort study.
(American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2021-06)We undertook a prospective, matched cohort study of patients with Staphylococcus aureus bacteremia (SAB) and gram-negative bacteremia (GNB) to compare the characteristics, outcomes, and chemokine and cytokine response in ... -
Bloodstream infections in community hospitals in the 21st century: a multicenter cohort study.
(PLoS One, 2014)BACKGROUND: While the majority of healthcare in the US is provided in community hospitals, the epidemiology and treatment of bloodstream infections in this setting is unknown. METHODS AND FINDINGS: We undertook this multicenter, ... -
Bonds between fibronectin and fibronectin-binding proteins on Staphylococcus aureus and Lactococcus lactis.
(Langmuir, 2010-07-06)Bacterial cell-wall-associated fibronectin binding proteins A and B (FnBPA and FnBPB) form bonds with host fibronectin. This binding reaction is often the initial step in prosthetic device infections. Atomic force microscopy ... -
CAMERA2 - combination antibiotic therapy for methicillin-resistant Staphylococcus aureus infection: study protocol for a randomised controlled trial.
(Trials, 2016-03-31)BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) bacteraemia is a serious infection resulting in 20-50 % 90-day mortality. The limitations of vancomycin, the current standard therapy for MRSA, make treatment ... -
Can ceftazidime/avibactam and aztreonam overcome β-lactam resistance conferred by metallo-β-lactamases in Enterobacteriaceae?
(Antimicrob Agents Chemother, 2017-02-06)Based upon knowledge of the hydrolytic profile of major β-lactamases found in Gram negative bacteria, we tested the effectiveness of the combination of ceftazidime/avibactam (CAZ/AVI) with aztreonam (ATM) against ... -
Candidate genes on murine chromosome 8 are associated with susceptibility to Staphylococcus aureus infection in mice and are involved with Staphylococcus aureus septicemia in humans.
(PloS one, 2017-01)We previously showed that chromosome 8 of A/J mice was associated with susceptibility to S. aureus infection. However, the specific genes responsible for this susceptibility are unknown. Chromosome substitution strain 8 ... -
Clinical outcomes and bacterial characteristics of carbapenem-resistant Klebsiella pneumoniae complex among patients from different global regions (CRACKLE-2): a prospective, multicentre, cohort study.
(The Lancet. Infectious diseases, 2021-11-09)<h4>Background</h4>Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a global threat. We therefore analysed the bacterial characteristics of CRKP infections and the clinical outcomes of patients with CRKP infections across ... -
Clinically Adjudicated Reference Standards for Evaluation of Infectious Diseases Diagnostics.
(Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023-03)Lack of a gold standard can present a challenge for evaluation of diagnostic test accuracy of some infectious diseases tests, particularly when the test's accuracy potentially exceeds that of its predecessors. This approach ... -
COVID-19-Lessons Learned and Questions Remaining.
(Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021-06)In this article, the editors of Clinical Infectious Diseases review some of the most important lessons they have learned about the epidemiology, clinical features, diagnosis, treatment and prevention of SARS-CoV-2 infection ... -
Delays in appropriate antibiotic therapy for gram-negative bloodstream infections: a multicenter, community hospital study.
(PLoS One, 2013)BACKGROUND: Gram-negative bacterial bloodstream infection (BSI) is a serious condition with estimated 30% mortality. Clinical outcomes for patients with severe infections improve when antibiotics are appropriately chosen ... -
Diagnosis of Capnocytophaga canimorsus Sepsis by Whole-Genome Next-Generation Sequencing.
(Open Forum Infect Dis, 2016-09)We report the case of a 60-year-old man with septic shock due to Capnocytophaga canimorsus that was diagnosed in 24 hours by a novel whole-genome next-generation sequencing assay. This technology shows great promise ... -
Discriminating Bacterial and Viral Infection Using a Rapid Host Gene Expression Test.
(Critical care medicine, 2021-10)<h4>Objectives</h4>Host gene expression signatures discriminate bacterial and viral infection but have not been translated to a clinical test platform. This study enrolled an independent cohort of patients to describe and ... -
Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis.
(PLoS Pathog, 2014-06)Using A/J mice, which are susceptible to Staphylococcus aureus, we sought to identify genetic determinants of susceptibility to S. aureus, and evaluate their function with regard to S. aureus infection. One QTL region on ...
