Browsing by Author "Fusco, Diana"
Now showing items 1-10 of 10
-
Characterizing protein crystal contacts and their role in crystallization: rubredoxin as a case study.
(Soft Matter, 2014-01-14)The fields of structural biology and soft matter have independently sought out fundamental principles to rationalize protein crystallization. Yet the conceptual differences and the limited overlap between the two disciplines ... -
Competition between monomeric and dimeric crystals in schematic models for globular proteins.
(J Phys Chem B, 2014-07-17)Advances in experimental techniques and in theoretical models have improved our understanding of protein crystallization. However, they have also left open questions regarding the protein phase behavior and self-assembly ... -
Crystallization of asymmetric patchy models for globular proteins in solution.
(Phys Rev E Stat Nonlin Soft Matter Phys, 2013-07)Asymmetric patchy particle models have recently been shown to describe the crystallization of small globular proteins with near-quantitative accuracy. Here, we investigate how asymmetry in patch geometry and bond energy ... -
Effects of polymorphism for locally adapted genes on rates of neutral introgression in structured populations.
(Theoretical population biology, 2011-09)Adaptation to local conditions within demes balanced by migration can maintain polymorphisms for variants that reduce fitness in certain ecological contexts. Here, we address the effects of such polymorphisms on the rate ... -
Learning about Biomolecular Solvation from Water in Protein Crystals.
(The journal of physical chemistry. B, 2018-03)Water occupies typically 50% of a protein crystal and thus significantly contributes to the diffraction signal in crystallography experiments. Separating its contribution from that of the protein is, however, challenging ... -
Ordered structure of the transcription network inherited from the yeast whole-genome duplication
(2010)Background: Gene duplication, a major evolutionary path to genomic innovation, can occur at the scale of an entire genome. One such "whole-genome duplication" (WGD) event among the Ascomycota fungi gave rise to genes with ... -
Protein Crystallization: Soft Matter and Chemical Physics Perspectives
(2014)X-ray and neutron crystallography are the predominant methods for obtaining atomic-scale information on bimolecular macromolecules. Despite the success of these techniques, generating well diffracting crystals critically ... -
Sex-specific incompatibility generates locus-specific rates of introgression between species.
(Genetics, 2011-09)Disruption of interactions among ensembles of epistatic loci has been shown to contribute to reproductive isolation among various animal and plant species. Under the Bateson-Dobzhansky-Muller model, such interspecific ... -
Soft matter perspective on protein crystal assembly.
(Colloids Surf B Biointerfaces, 2016-01-01)Crystallography may be the gold standard of protein structure determination, but obtaining the necessary high-quality crystals is also in some ways akin to prospecting for the precious metal. The tools and models developed ... -
Statistical analysis of crystallization database links protein physico-chemical features with crystallization mechanisms.
(PLoS One, 2014)X-ray crystallography is the predominant method for obtaining atomic-scale information about biological macromolecules. Despite the success of the technique, obtaining well diffracting crystals still critically limits going ...
