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Browsing by Author "Gainetdinov, Raul R"

Now showing items 1-4 of 4

    • Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice. 

      Bohn, Laura M; Gainetdinov, Raul R; Sotnikova, Tatyana D; Medvedev, Ivan O; Lefkowitz, Robert J; Dykstra, Linda A; Caron, Marc G (J Neurosci, 2003-11-12)
      The reinforcing and psychomotor effects of morphine involve opiate stimulation of the dopaminergic system via activation of mu-opioid receptors (muOR). Both mu-opioid and dopamine receptors are members of the G-protein-coupled ...

    • Social context-dependent singing-regulated dopamine. 

      Sasaki, Aya; Sotnikova, Tatyana D; Gainetdinov, Raul R; Jarvis, Erich D (J Neurosci, 2006-08-30)
      Like the mammalian striatum, the songbird striatum receives dense dopaminergic input from the midbrain ventral tegmental area-substantia nigra pars compacta complex. The songbird striatum also contains a unique vocal nucleus, ...

    • The dopamine metabolite 3-methoxytyramine is a neuromodulator. 

      Sotnikova, Tatyana D; Beaulieu, Jean-Martin; Espinoza, Stefano; Masri, Bernard; Zhang, Xiaodong; Salahpour, Ali; Barak, Larry S; ... (9 authors) (PLoS One, 2010-10-18)
      Dopamine (3-hydroxytyramine) is a well-known catecholamine neurotransmitter involved in multiple physiological functions including movement control. Here we report that the major extracellular metabolite of dopamine, ...

    • The role of GRK6 in animal models of Parkinson's disease and L-DOPA treatment. 

      Managò, Francesca; Espinoza, Stefano; Salahpour, Ali; Sotnikova, Tatyana D; Caron, Marc G; Premont, Richard T; Gainetdinov, Raul R (Sci Rep, 2012)
      G protein-coupled Receptor Kinase 6 (GRK6) belongs to a family of kinases that phosphorylate GPCRs. GRK6 levels were found to be altered in Parkinson's Disease (PD) and D(2) dopamine receptors are supersensitive in mice ...