Browsing by Author "Garcia-Blanco, Mariano A"
Now showing items 1-7 of 7
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Alternative splicing in multiple sclerosis and other autoimmune diseases.
(RNA Biol, 2010-07)Alternative splicing is a general mechanism for regulating gene expression that affects the RNA products of more than 90% of human genes. Not surprisingly, alternative splicing is observed among gene products of metazoan ... -
Development of a Novel c-MET-Based CTC Detection Platform.
(Mol Cancer Res, 2016-06)UNLABELLED: Amplification of the MET oncogene is associated with poor prognosis, metastatic dissemination, and drug resistance in many malignancies. We developed a method to capture and characterize circulating tumor cells ... -
Epstein-Barr virus induces global changes in cellular mRNA isoform usage that are important for the maintenance of latency.
(Journal of virology, 2013-11)Oncogenic viruses promote cell proliferation through the dramatic reorganization of host transcriptomes. In addition to regulating mRNA abundance, changes in mRNA isoform usage can have a profound impact on the protein output ... -
Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2.
(Mol Cell Biol, 2016-10-01)Phenotypic plasticity involves a process in which cells transiently acquire phenotypic traits of another lineage. Two commonly studied types of phenotypic plasticity are epithelial-mesenchymal transition (EMT) and ... -
Snail promotes resistance to enzalutamide through regulation of androgen receptor activity in prostate cancer.
(Oncotarget, 2016-08-02)Treatment with androgen-targeted therapies can induce upregulation of epithelial plasticity pathways. Epithelial plasticity is known to be important for metastatic dissemination and therapeutic resistance. The goal of this ... -
SplicerAV: a tool for mining microarray expression data for changes in RNA processing.
(BMC Bioinformatics, 2010-02-25)BACKGROUND: Over the past two decades more than fifty thousand unique clinical and biological samples have been assayed using the Affymetrix HG-U133 and HG-U95 GeneChip microarray platforms. This substantial repository has ... -
SplicerEX: a tool for the automated detection and classification of mRNA changes from conventional and splice-sensitive microarray expression data.
(RNA (New York, N.Y.), 2012-08)The key postulate that one gene encodes one protein has been overhauled with the discovery that one gene can generate multiple RNA transcripts through alternative mRNA processing. In this study, we describe SplicerEX, a ...
