Browsing by Author "Garrett, Melanie E"

An epigenome-wide association study of posttraumatic stress disorder in US veterans implicates several new DNA methylation loci.

Logue, Mark W; Miller, Mark W; Wolf, Erika J; Huber, Bertrand Russ; Morrison, Filomene G; Zhou, Zhenwei; Zheng, Yuanchao; ... (39 authors) (Clinical epigenetics, 2020-03)

<h4>Background</h4>Previous studies using candidate gene and genome-wide approaches have identified epigenetic changes in DNA methylation (DNAm) associated with posttraumatic stress disorder (PTSD).<h4>Methods</h4>In this ...

Gene Expression Analysis in Three Posttraumatic Stress Disorder Cohorts Implicates Inflammation and Innate Immunity Pathways and Uncovers Shared Genetic Risk With Major Depressive Disorder.

Garrett, Melanie E; Qin, Xue Jun; Mehta, Divya; Dennis, Michelle F; Marx, Christine E; Grant, Gerald A; VA Mid-Atlantic MIRECC Workgroup; ... (15 authors) (Frontiers in neuroscience, 2021-01)

Posttraumatic stress disorder (PTSD) is a complex psychiatric disorder that can develop following exposure to traumatic events. The Psychiatric Genomics Consortium PTSD group (PGC-PTSD) has collected over 20,000 multi-ethnic ...

In vivo Modeling Implicates APOL1 in Nephropathy: Evidence for Dominant Negative Effects and Epistasis under Anemic Stress.

Anderson, Blair R; Howell, David N; Soldano, Karen; Garrett, Melanie E; Katsanis, Nicholas; Telen, Marilyn J; Davis, Erica E; ... (8 authors) (PLoS Genet, 2015-07)

African Americans have a disproportionate risk for developing nephropathy. This disparity has been attributed to coding variants (G1 and G2) in apolipoprotein L1 (APOL1); however, there is little functional evidence supporting ...

Joint eQTL assessment of whole blood and dura mater tissue from individuals with Chiari type I malformation.

Lock, Eric F; Soldano, Karen L; Garrett, Melanie E; Cope, Heidi; Markunas, Christina A; Fuchs, Herbert; Grant, Gerald; ... (10 authors) (BMC Genomics, 2015-01-22)

BACKGROUND: Expression quantitative trait loci (eQTL) play an important role in the regulation of gene expression. Gene expression levels and eQTLs are expected to vary from tissue to tissue, and therefore multi-tissue analyses ...

The genetic architecture of the human cerebral cortex.

Grasby, Katrina L; Jahanshad, Neda; Painter, Jodie N; Colodro-Conde, Lucía; Bralten, Janita; Hibar, Derrek P; Lind, Penelope A; ... (367 authors) (Science (New York, N.Y.), 2020-03)

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, ...