Browsing by Author "Ginsburg, Geoffrey S"
Now showing items 1-20 of 46
-
A blood-based host gene expression assay for early detection of respiratory viral infection: an index-cluster prospective cohort study.
(The Lancet. Infectious diseases, 2020-09-24)BACKGROUND:Early and accurate identification of individuals with viral infections is crucial for clinical management and public health interventions. We aimed to assess the ability of transcriptomic biomarkers to identify ... -
A crowdsourced analysis to identify ab initio molecular signatures predictive of susceptibility to viral infection.
(Nature communications, 2018-10-24)The response to respiratory viruses varies substantially between individuals, and there are currently no known molecular predictors from the early stages of infection. Here we conduct a community-based analysis to determine ... -
A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.
(Open Forum Infect Dis, 2016-01)Early, presymptomatic intervention with oseltamivir (corresponding to the onset of a published host-based genomic signature of influenza infection) resulted in decreased overall influenza symptoms (aggregate symptom scores ... -
A host gene expression approach for identifying triggers of asthma exacerbations.
(PloS one, 2019-01)RATIONALE:Asthma exacerbations often occur due to infectious triggers, but determining whether infection is present and whether it is bacterial or viral remains clinically challenging. A diagnostic strategy that clarifies ... -
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
(PLoS One, 2013)There is great potential for host-based gene expression analysis to impact the early diagnosis of infectious diseases. In particular, the influenza pandemic of 2009 highlighted the challenges and limitations of traditional ... -
A miRNA Host Response Signature Accurately Discriminates Acute Respiratory Infection Etiologies.
(Frontiers in microbiology, 2018-01)Background: Acute respiratory infections (ARIs) are the leading indication for antibacterial prescriptions despite a viral etiology in the majority of cases. The lack of available diagnostics to discriminate viral and bacterial ... -
An integrated transcriptome and expressed variant analysis of sepsis survival and death.
(Genome Med, 2014)BACKGROUND: Sepsis, a leading cause of morbidity and mortality, is not a homogeneous disease but rather a syndrome encompassing many heterogeneous pathophysiologies. Patient factors including genetics predispose to poor ... -
Assessment of the Feasibility of Using Noninvasive Wearable Biometric Monitoring Sensors to Detect Influenza and the Common Cold Before Symptom Onset.
(JAMA network open, 2021-09)<h4>Importance</h4>Currently, there are no presymptomatic screening methods to identify individuals infected with a respiratory virus to prevent disease spread and to predict their trajectory for resource allocation.<h4>... -
Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events.
(Circ Cardiovasc Genet, 2010-04)BACKGROUND: Molecular tools may provide insight into cardiovascular risk. We assessed whether metabolites discriminate coronary artery disease (CAD) and predict risk of cardiovascular events. METHODS AND RESULTS: We performed ... -
Bayesian inference of the number of factors in gene-expression analysis: application to human virus challenge studies
(BMC BIOINFORMATICS, 2010-11-09) -
Challenges and strategies for implementing genomic services in diverse settings: experiences from the Implementing GeNomics In pracTicE (IGNITE) network.
(BMC Med Genomics, 2017-05-22)BACKGROUND: To realize potential public health benefits from genetic and genomic innovations, understanding how best to implement the innovations into clinical care is important. The objective of this study was to synthesize ... -
Chromatin remodeling in peripheral blood cells reflects COVID-19 symptom severity.
(bioRxiv, 2020-12-05)SARS-CoV-2 infection triggers highly variable host responses and causes varying degrees of illness in humans. We sought to harness the peripheral blood mononuclear cell (PBMC) response over the course of illness to provide ... -
Clinical implementation of an oncology-specific family health history risk assessment tool.
(Hereditary cancer in clinical practice, 2021-03-20)<h4>Background</h4>The presence of hereditary cancer syndromes in cancer patients can have an impact on current clinical care and post-treatment prevention and surveillance measures. Several barriers inhibit identification ... -
Clinical utility of a Web-enabled risk-assessment and clinical decision support program.
(Genet Med, 2016-10)PURPOSE: Risk-stratified guidelines can improve quality of care and cost-effectiveness, but their uptake in primary care has been limited. MeTree, a Web-based, patient-facing risk-assessment and clinical decision support ... -
Development of a blood-based gene expression algorithm for assessment of obstructive coronary artery disease in non-diabetic patients.
(BMC Med Genomics, 2011-03-28)BACKGROUND: Alterations in gene expression in peripheral blood cells have been shown to be sensitive to the presence and extent of coronary artery disease (CAD). A non-invasive blood test that could reliably assess obstructive ... -
Discriminating Bacterial and Viral Infection Using a Rapid Host Gene Expression Test.
(Critical care medicine, 2021-10)<h4>Objectives</h4>Host gene expression signatures discriminate bacterial and viral infection but have not been translated to a clinical test platform. This study enrolled an independent cohort of patients to describe and ... -
Dysregulated transcriptional responses to SARS-CoV-2 in the periphery support novel diagnostic approaches.
(medRxiv, 2020-07-26)In order to elucidate novel aspects of the host response to SARS-CoV-2 we performed RNA sequencing on peripheral blood samples across 77 timepoints from 46 subjects with COVID-19 and compared them to subjects with seasonal ... -
Dysregulated transcriptional responses to SARS-CoV-2 in the periphery.
(Nature communications, 2021-02-17)SARS-CoV-2 infection has been shown to trigger a wide spectrum of immune responses and clinical manifestations in human hosts. Here, we sought to elucidate novel aspects of the host response to SARS-CoV-2 infection through ... -
Effect of genetic testing for risk of type 2 diabetes mellitus on health behaviors and outcomes: study rationale, development and design.
(BMC Health Serv Res, 2012-01-18)BACKGROUND: Type 2 diabetes is a prevalent chronic condition globally that results in extensive morbidity, decreased quality of life, and increased health services utilization. Lifestyle changes can prevent the development ... -
Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network.
(Genetics in medicine : official journal of the American College of Medical Genetics, 2021-03-29)<h4>Purpose</h4>A critical gap in the adoption of genomic medicine into medical practice is the need for the rigorous evaluation of the utility of genomic medicine interventions.<h4>Methods</h4>The Implementing Genomics ...
