Browsing by Author "Glickman, Seth W"
Now showing items 1-8 of 8
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An integrated transcriptome and expressed variant analysis of sepsis survival and death.
(Genome Med, 2014)BACKGROUND: Sepsis, a leading cause of morbidity and mortality, is not a homogeneous disease but rather a syndrome encompassing many heterogeneous pathophysiologies. Patient factors including genetics predispose to poor ... -
Are patients with longer emergency department wait times less likely to consent to research?
(Acad Emerg Med, 2012-04)OBJECTIVES: There are unique challenges to enrolling patients in emergency department (ED) clinical research studies, including the time-sensitive nature of emergency conditions, the acute care environment, and the lack ... -
Discriminating Bacterial and Viral Infection Using a Rapid Host Gene Expression Test.
(Critical care medicine, 2021-10)<h4>Objectives</h4>Host gene expression signatures discriminate bacterial and viral infection but have not been translated to a clinical test platform. This study enrolled an independent cohort of patients to describe and ... -
Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans.
(PLoS One, 2013)Staphylococcus aureus causes a spectrum of human infection. Diagnostic delays and uncertainty lead to treatment delays and inappropriate antibiotic use. A growing literature suggests the host's inflammatory response to the ... -
Host gene expression classifiers diagnose acute respiratory illness etiology.
(Sci Transl Med, 2016-01-20)Acute respiratory infections caused by bacterial or viral pathogens are among the most common reasons for seeking medical care. Despite improvements in pathogen-based diagnostics, most patients receive inappropriate antibiotics. ... -
Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients.
(Ann Am Thorac Soc, 2016-03)RATIONALE: Limitations in methods for the rapid diagnosis of hospital-acquired infections often delay initiation of effective antimicrobial therapy. New diagnostic approaches offer potential clinical and cost-related improvements ... -
Renal systems biology of patients with systemic inflammatory response syndrome.
(Kidney Int, 2015-10)A systems biology approach was used to comprehensively examine the impact of renal disease and hemodialysis (HD) on patient response during critical illness. To achieve this, we examined the metabolome, proteome, ... -
Validation of a host response test to distinguish bacterial and viral respiratory infection.
(EBioMedicine, 2019-10-17)BACKGROUND:Distinguishing bacterial and viral respiratory infections is challenging. Novel diagnostics based on differential host gene expression patterns are promising but have not been translated to a clinical platform ...
