Browsing by Author "Grill, Warren M"
Now showing items 1-9 of 9
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Design and in vivo evaluation of more efficient and selective deep brain stimulation electrodes.
(Journal of neural engineering, 2015-08)<h4>Objective</h4>Deep brain stimulation (DBS) is an effective treatment for movement disorders and a promising therapy for treating epilepsy and psychiatric disorders. Despite its clinical success, the efficiency and selectivity ... -
Effects of Electrical Stimulation in the Inferior Colliculus on Frequency Discrimination by Rhesus Monkeys and Implications for the Auditory Midbrain Implant.
(The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016-05)Understanding the relationship between the auditory selectivity of neurons and their contribution to perception is critical to the design of effective auditory brain prosthetics. These prosthetics seek to mimic natural activity ... -
Effects of frequency-dependent membrane capacitance on neural excitability.
(Journal of neural engineering, 2015-10)<h4>Objective</h4>Models of excitable cells consider the membrane specific capacitance as a ubiquitous and constant parameter. However, experimental measurements show that the membrane capacitance declines with increasing ... -
Evaluation of high-perimeter electrode designs for deep brain stimulation.
(Journal of neural engineering, 2014-08)<h4>Objective</h4>Deep brain stimulation (DBS) is an effective treatment for movement disorders and a promising therapy for treating epilepsy and psychiatric disorders. Despite its clinical success, complications including ... -
Evaluation of intradural stimulation efficiency and selectivity in a computational model of spinal cord stimulation.
(PloS one, 2014-01)Spinal cord stimulation (SCS) is an alternative or adjunct therapy to treat chronic pain, a prevalent and clinically challenging condition. Although SCS has substantial clinical success, the therapy is still prone to failures, ... -
Influences of interpolation error, electrode geometry, and the electrode-tissue interface on models of electric fields produced by deep brain stimulation.
(IEEE transactions on bio-medical engineering, 2014-02)Deep brain stimulation (DBS) is an established therapy for movement disorders, but the fundamental mechanisms by which DBS has its effects remain unknown. Computational models can provide insights into the mechanisms of ... -
Initial Clinical Outcome With Bilateral, Dual-Target Deep Brain Stimulation Trial in Parkinson Disease Using Summit RC + S.
(Neurosurgery, 2022-04-07)<h4>Background</h4>Deep brain stimulation (DBS) is an effective therapy in advanced Parkinson disease (PD). Although both subthalamic nucleus (STN) and globus pallidus (GP) DBS show equivalent efficacy in PD, combined stimulation ... -
Simultaneous transcranial magnetic stimulation and single-neuron recording in alert non-human primates.
(Nat Neurosci, 2014-08)Transcranial magnetic stimulation (TMS) is a widely used, noninvasive method for stimulating nervous tissue, yet its mechanisms of effect are poorly understood. Here we report new methods for studying the influence of TMS ... -
Stimulation Efficiency With Decaying Exponential Waveforms in a Wirelessly Powered Switched-Capacitor Discharge Stimulation System.
(IEEE transactions on bio-medical engineering, 2018-05)The purpose of this study was to test the feasibility of using a switched-capacitor discharge stimulation (SCDS) system for electrical stimulation, and, subsequently, determine the overall energy saved compared to a conventional ...
