Browsing by Author "Guan, Ziqiang"
Now showing items 1-20 of 20
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1,2-Diacylglycerol choline phosphotransferase catalyzes the final step in the unique Treponema denticola phosphatidylcholine biosynthesis pathway.
(Mol Microbiol, 2016-12-23)Treponema denticola synthesizes phosphatidylcholine through a licCA-dependent CDP-choline pathway identified only in the genus Treponema. However, the mechanism of conversion of CDP-choline to phosphatidylcholine remained ... -
A Mitochondrial Lipid Phosphatase in Cell Metabolism and Membrane Organization
(FASEB JOURNAL, 2010-04) -
Caulobacter crescentus Adapts to Phosphate Starvation by Synthesizing Anionic Glycoglycerolipids and a Novel Glycosphingolipid.
(mBio, 2019-04-02)Caulobacter crescentus adapts to phosphate starvation by elongating its cell body and a polar stalk structure. The stalk is an extension of the Gram-negative envelope containing inner and outer membranes as well ... -
Discovery of the Elusive UDP-Diacylglucosamine Hydrolase in the Lipid A Biosynthetic Pathway in Chlamydia trachomatis.
(MBio, 2016-03-22)Constitutive biosynthesis of lipid A via the Raetz pathway is essential for the viability and fitness of Gram-negative bacteria, includingChlamydia trachomatis Although nearly all of the enzymes in the lipid A biosynthetic ... -
Gene deletions leading to a reduction in the number of cyclopentane rings in Sulfolobus acidocaldarius tetraether lipids.
(FEMS Microbiol Lett, 2017-11-29)The cell membrane of (hyper)thermophilic archaea, including the thermoacidophile Sulfolobus acidocaldarius, incorporate dibiphytanylglycerol tetraether lipids. The hydrophobic cores of such tetraether lipids can include ... -
Identifying a Novel Connection Between the Fungal Plasma Membrane and pH-Sensing.
(Molecular microbiology, 2018-06-08)The mechanisms by which micro-organisms sense and internalize extracellular pH signals are not completely understood. One example of a known external pH-sensing process is the fungal-specific Rim/Pal signal transduction ... -
In Vivo and in Vitro Synthesis of Phosphatidylglycerol by an Escherichia coli Cardiolipin Synthase.
(J Biol Chem, 2016-11-25)Phosphatidylglycerol (PG) makes up 5-20% of the phospholipids of Escherichia coli and is essential for growth in wild-type cells. PG is synthesized from the dephosphorylation of its immediate precursor, phosphatidylglycerol ... -
MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis
(Nature Metabolism, 2020-01-01)© 2020, The Author(s), under exclusive licence to Springer Nature Limited. Critical to the bacterial stringent response is the rapid relocation of resources from proliferation toward stress survival through the respective ... -
N-glycosylation in the thermoacidophilic archaeon Sulfolobus acidocaldarius involves a short dolichol pyrophosphate carrier.
(FEBS Lett, 2016-09)N-glycosylation is a post-translational modification that occurs across evolution. In the thermoacidophilic archaea Sulfolobus acidocaldarius, glycoproteins are modified by an N-linked tribranched hexasaccharide reminiscent ... -
NgBR is essential for endothelial cell glycosylation and vascular development.
(EMBO Rep, 2016-02)NgBR is a transmembrane protein identified as a Nogo-B-interacting protein and recently has been shown to be a subunit required for cis-prenyltransferase (cisPTase) activity. To investigate the integrated role of NgBR in ... -
Ornithine Lipids in Burkholderia spp. Pathogenicity.
(Frontiers in molecular biosciences, 2020-01)The genus Burkholderia sensu lato is composed of a diverse and metabolically versatile group of bacterial species. One characteristic thought to be unique for the genus Burkholderia is the presence of two forms each (with ... -
Outer Membrane Vesiculation Facilitates Surface Exchange and In Vivo Adaptation of Vibrio cholerae.
(Cell host & microbe, 2019-12-23)Gram-negative bacteria release outer membrane vesicles into the external milieu to deliver effector molecules that alter the host and facilitate virulence. Vesicle formation is driven by phospholipid accumulation in the ... -
Phosphatidylcholine biosynthesis in Mitis group streptococci via host metabolite scavenging.
(Journal of bacteriology, 2019-09-09)The Mitis group streptococci include the major human pathogen Streptococcus pneumoniae and the opportunistic pathogens S. mitis and S. oralis which are human oral cavity colonizers and agents of bacteremia and infective ... -
Quantifying lipofuscin in retinal pigment epithelium in vivo by visible-light optical coherence tomography-based multimodal imaging.
(Scientific reports, 2020-02-19)Lipofuscin in the retinal pigment epithelium (RPE) is the major source of fundus autofluorescence (FAF). A technical challenge to accurately quantify the FAF intensities, thus the lipofuscin concentration, is to compensate ... -
Streptococcus mitis and S. oralis lack a requirement for CdsA, the enzyme required for synthesis of major membrane phospholipids in bacteria.
(Antimicrob Agents Chemother, 2017-02-21)Synthesis and integrity of the cytoplasmic membrane is fundamental to cellular life. Experimental evolution studies have hinted at unique physiology in the Gram-positive bacteria Streptococcus mitis and S. oralis These organisms ... -
Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis.
(Nat Commun, 2016-01-05)The attachment of a sugar to a hydrophobic polyisoprenyl carrier is the first step for all extracellular glycosylation processes. The enzymes that perform these reactions, polyisoprenyl-glycosyltransferases (PI-GTs) include ... -
The cellular lipids of Romboutsia.
(Biochim Biophys Acta, 2016-09)We have examined the lipids of three isolates, Romboutsia lituseburensis, Romboutsia ilealis, and Romboutsia sp. strain FRIFI, of the newly described genus Romboutsia by two-dimensional thin-layer chromatography (2D-TLC) ... -
The human UDP-galactose 4'-epimerase (GALE) is required for cell-surface glycome structure and function.
(The Journal of biological chemistry, 2019-12-09)Glycan biosynthesis relies on nucleotidesugars (NS), abundant metabolites that serve as monosaccharide donors for glycosyltransferases. In vivo, signal-dependent fluctuations in NS levels are required to maintain normal ... -
The Lipid A 1-Phosphatase, LpxE, Functionally Connects Multiple Layers of Bacterial Envelope Biogenesis.
(mBio, 2019-06-18)Although distinct lipid phosphatases are thought to be required for processing lipid A (component of the outer leaflet of the outer membrane), glycerophospholipid (component of the inner membrane and the inner leaflet of ... -
The phospholipid-repair system LplT/Aas in Gram-negative bacteria protects the bacterial membrane envelope from host phospholipase A2 attack.
(J Biol Chem, 2018-01-18)Secretory phospholipases A2 (sPLA2) are potent components of mammalian innate-immunity antibacterial mechanisms. sPLA2 enzymes attack bacteria by hydrolyzing bacterial membrane phospholipids, causing membrane disorganization ...
