Browsing by Author "Guptill, Jeffrey T"
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B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity.
Yi, John S; Russo, Melissa A; Massey, Janice M; Juel, Vern; Hobson-Webb, Lisa D; Gable, Karissa; Raja, Shruti M; ... (10 authors) (Front Neurol, 2017)Myasthenia gravis (MG) is a T cell-dependent, B cell-mediated disease. The mechanisms for loss of self-tolerance in this disease are not well understood, and recently described regulatory B cell (Breg) subsets have not been ... -
Characterization of B cells in muscle-specific kinase antibody myasthenia gravis.
Guptill, Jeffrey T; Yi, John S; Sanders, Donald B; Guidon, Amanda C; Juel, Vern C; Massey, Janice M; Howard, James F; ... (11 authors) (Neurol Neuroimmunol Neuroinflamm, 2015-04)OBJECTIVE: To characterize B-cell subsets in patients with muscle-specific tyrosine kinase (MuSK) myasthenia gravis (MG). METHODS: In accordance with Human Immunology Project Consortium guidelines, we performed polychromatic ... -
Establishment of normative ranges of the healthy human immune system with comprehensive polychromatic flow cytometry profiling.
Yi, John S; Rosa-Bray, Marilyn; Staats, Janet; Zakroysky, Pearl; Chan, Cliburn; Russo, Melissa A; Dumbauld, Chelsae; ... (11 authors) (PloS one, 2019-01)Existing normative flow cytometry data have several limitations including small sample sizes, incompletely described study populations, variable flow cytometry methodology, and limited depth for defining lymphocyte ... -
Normative dataset for plasma cytokines in healthy human adults.
Li, Yingkai; Yi, John S; Russo, Melissa A; Rosa-Bray, Marilyn; Weinhold, Kent J; Guptill, Jeffrey T (Data in brief, 2021-04)We determined normative data for plasma cytokines established from a cohort of 126 carefully screened healthy adults aged 18 to 64 years. Participants were enrolled to ensure an even age and sex distribution and to include ... -
Prolonged B-cell depletion in MuSK myasthenia gravis following rituximab treatment.
Yi, John S; Decroos, Emily C; Sanders, Donald B; Weinhold, Kent J; Guptill, Jeffrey T (Muscle Nerve, 2013-12)