Now showing items 1-12 of 12

    • Association between XPF polymorphisms and cancer risk: a meta-analysis. 

      Shi, Ting-Yan; He, Jing; Qiu, Li-Xin; Zhu, Mei-Ling; Wang, Meng-Yun; Zhou, Xiao-Yan; Han, Jiali; ... (10 authors) (PloS one, 2012-01)
      BACKGROUND: Xeroderma pigmentosum complementation group F (XPF or ERCC4) plays a key role in DNA repair that protects against genetic instability and carcinogenesis. A series of epidemiological studies have examined associations ...
    • Associations between smoking behavior-related alleles and the risk of melanoma. 

      Wu, Wenting; Liu, Hongliang; Song, Fengju; Chen, Li-Shiun; Kraft, Peter; Wei, Qingyi; Han, Jiali (Oncotarget, 2016-07-26)
      Several studies have reported that cigarette smoking is inversely associated with the risk of melanoma. This study further tested whether incorporating genetic factors will provide another level of evaluation of mechanisms ...
    • Genetic variants in RORA and DNMT1 associated with cutaneous melanoma survival. 

      Li, Bo; Wang, Yanru; Xu, Yinghui; Liu, Hongliang; Bloomer, Wendy; Zhu, Dakai; Amos, Christopher I; ... (12 authors) (International journal of cancer, 2018-06)
      Cutaneous melanoma (CM) is considered as a steroid hormone-related malignancy. However, few studies have evaluated the roles of genetic variants encoding steroid hormone receptor genes and their related regulators (SHR-related ...
    • Genetic variants in the metzincin metallopeptidase family genes predict melanoma survival. 

      Xu, Yinghui; Wang, Yanru; Liu, Hongliang; Shi, Qiong; Zhu, Dakai; Amos, Christopher I; Fang, Shenying; ... (12 authors) (Molecular carcinogenesis, 2018-01)
      Metzincins are key molecules in the degradation of the extracellular matrix and play an important role in cellular processes such as cell migration, adhesion, and cell fusion of malignant tumors, including cutaneous melanoma ...
    • Genetic variants of PDGF signaling pathway genes predict cutaneous melanoma survival. 

      Li, Hong; Wang, Yanru; Liu, Hongliang; Shi, Qiong; Li, Hongyu; Wu, Wenting; Zhu, Dakai; ... (13 authors) (Oncotarget, 2017-09)
      To investigate whether genetic variants of platelet-derived growth factor (PDGF) signaling pathway genes are associated with survival of cutaneous melanoma (CM) patients, we assessed associations of single-nucleotide ...
    • Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3. 

      Macgregor, Stuart; Montgomery, Grant W; Liu, Jimmy Z; Zhao, Zhen Zhen; Henders, Anjali K; Stark, Mitchell; Schmid, Helen; ... (52 authors) (Nature genetics, 2011-10-09)
      We performed a genome-wide association study of melanoma in a discovery cohort of 2,168 Australian individuals with melanoma and 4,387 control individuals. In this discovery phase, we confirm several previously characterized ...
    • Genome-wide association study identifies three new melanoma susceptibility loci. 

      Barrett, Jennifer H; Iles, Mark M; Harland, Mark; Taylor, John C; Aitken, Joanne F; Andresen, Per Arne; Akslen, Lars A; ... (76 authors) (Nature genetics, 2011-10-09)
      We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control individuals of European ancestry, ...
    • Inverse Relationship between Vitiligo-Related Genes and Skin Cancer Risk. 

      Wu, Wenting; 23andMe Research Team; Amos, Christopher I; Lee, Jeffrey E; Wei, Qingyi; Sarin, Kavita Y; Han, Jiali (The Journal of investigative dermatology, 2018-09)
    • Joint effect of multiple common SNPs predicts melanoma susceptibility. 

      Fang, Shenying; Han, Jiali; Zhang, Mingfeng; Wang, Li-e; Wei, Qingyi; Amos, Christopher I; Lee, Jeffrey E (PloS one, 2013-01)
      Single genetic variants discovered so far have been only weakly associated with melanoma. This study aims to use multiple single nucleotide polymorphisms (SNPs) jointly to obtain a larger genetic effect and to improve the ...
    • Novel genetic variants of PIP5K1C and MVB12B of the endosome-related pathway predict cutaneous melanoma-specific survival. 

      Lu, Guiqing; Zhou, Bingrong; He, Yuanmin; Liu, Hongliang; Luo, Sheng; Amos, Christopher I; Lee, Jeffrey E; ... (11 authors) (American journal of cancer research, 2020-01)
      Endosomes regulate cell polarity, adhesion, signaling, immunity, and tumor progression, which may influence cancer outcomes. Here we evaluated associations between 36,068 genetic variants of 228 endosome-related pathway ...
    • Plasma miRNAs as early biomarkers for detecting hepatocellular carcinoma. 

      Wen, Yang; Han, Jing; Chen, Jianguo; Dong, Jing; Xia, Yongxiang; Liu, Jibin; Jiang, Yue; ... (15 authors) (Int J Cancer, 2015-10-01)
      The early detection of hepatocellular carcinoma (HCC) presents a challenge because of the lack of specific biomarkers. Serum/plasma microRNAs (miRNAs) can discriminate HCC patients from controls. We aimed to identify and ...
    • Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma. 

      Ransohoff, Katherine J; Wu, Wenting; Cho, Hyunje G; Chahal, Harvind C; Lin, Yuan; Dai, Hong-Ji; Amos, Christopher I; ... (13 authors) (Oncotarget, 2017-03)
      Genome-wide association studies have identified 21 susceptibility loci associated with melanoma. These loci implicate genes affecting pigmentation, nevus count, telomere maintenance, and DNA repair in melanoma risk. Here, ...