Now showing items 1-7 of 7

    • A flexible statistical model for alignment of label-free proteomics data--incorporating ion mobility and product ion information. 

      Benjamin, Ashlee M; Geromanos, SJ; Henao, R; Kraus, Virginia Byers; Lucas, Joseph E; Moseley, Martin Arthur III; Soderblom, Erik James; ... (8 authors) (BMC Bioinformatics, 2013-12-16)
      BACKGROUND: The goal of many proteomics experiments is to determine the abundance of proteins in biological samples, and the variation thereof in various physiological conditions. High-throughput quantitative proteomics, ...
    • A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53. 

      Dewhirst, Mark Wesley; Geradts, J; Henao, R; Kim, J; Kim, WJ; Kornbluth, S; Kurokawa, M; ... (15 authors) (Sci Signal, 2013-05-07)
      In the intrinsic pathway of apoptosis, cell-damaging signals promote the release of cytochrome c from mitochondria, triggering activation of the Apaf-1 and caspase-9 apoptosome. The ubiquitin E3 ligase MDM2 decreases the ...
    • An integrated transcriptome and expressed variant analysis of sepsis survival and death. 

      Cairns, CB; Carin, Lawrence; Corey, GR; Dinwiddie, DL; Fowler, Vance Garrison Jr; Ginsburg, Geoffrey Steven; Glickman, Seth W; ... (24 authors) (Genome Med, 2014)
      BACKGROUND: Sepsis, a leading cause of morbidity and mortality, is not a homogeneous disease but rather a syndrome encompassing many heterogeneous pathophysiologies. Patient factors including genetics predispose to poor ...
    • Host gene expression classifiers diagnose acute respiratory illness etiology. 

      Burke, T; Cairns, CB; Carin, Lawrence; Fowler, Vance Garrison Jr; Freeman, DH; Ginsburg, Geoffrey Steven; Glickman, Seth W; ... (24 authors) (Sci Transl Med, 2016-01-20)
      Acute respiratory infections caused by bacterial or viral pathogens are among the most common reasons for seeking medical care. Despite improvements in pathogen-based diagnostics, most patients receive inappropriate antibiotics. ...
    • Latent protein trees 

      Carin, Lawrence; Ginsburg, Geoffrey Steven; Henao, R; Lucas, Joseph E; Moseley, Martin Arthur III; Thompson, JW (Annals of Applied Statistics, 2013-06-01)
      Unbiased, label-free proteomics is becoming a powerful technique for measuring protein expression in almost any biological sample. The output of these measurements after preprocessing is a collection of features and their ...
    • Learning a hybrid architecture for sequence regression and annotation 

      Carin, Lawrence; Hartemink, Alexander J; Henao, R; Zhang, Y; Zhong, J (30th AAAI Conference on Artificial Intelligence, AAAI 2016, 2016-01-01)
      © Copyright 2016, Association for the Advancement of Artificial Intelligence (www.aaai.org). All rights reserved.When learning a hidden Markov model (HMM), sequential observations can often be complemented by real-valued ...
    • Non-Gaussian discriminative factor models via the max-margin rank-likelihood 

      Carin, Lawrence; Henao, R; Langley, RJ; Tsalik, Ephraim L; Yuan, X (32nd International Conference on Machine Learning, ICML 2015, 2015-01-01)
      Copyright © 2015 by the author(s).We consider the problem of discriminative factor analysis for data that are in general non-Gaussian. A Bayesian model based on the ranks of the data is proposed. We first introduce a new ...