Now showing items 1-2 of 2

    • c-Myc is required for maintenance of glioma cancer stem cells. 

      Wang, J; Wang, H; Li, Z; Wu, Q; Lathia, JD; McLendon, RE; Hjelmeland, AB; ... (8 authors) (PLoS One, 2008)
      BACKGROUND: Malignant gliomas rank among the most lethal cancers. Gliomas display a striking cellular heterogeneity with a hierarchy of differentiation states. Recent studies support the existence of cancer stem cells in ...
    • Targeting A20 decreases glioma stem cell survival and tumor growth. 

      Hjelmeland, AB; Wu, Q; Wickman, S; Eyler, C; Heddleston, J; Shi, Q; Lathia, JD; ... (11 authors) (PLoS Biol, 2010-02-23)
      Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the bulk tumor that may be ...