Now showing items 1-6 of 6

    • Age-related changes in the cellular composition and epithelial organization of the mouse trachea. 

      Wansleeben, Carolien; Bowie, Emily; Hotten, Danielle F; Yu, Yen-Rei A; Hogan, Brigid LM (PloS one, 2014-01)
      We report here senescent changes in the structure and organization of the mucociliary pseudostratified epithelium of the mouse trachea and main stem bronchi. We confirm previous reports of the gradual appearance of age-related, ...
    • Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling. 

      Rock, Jason R; Randell, Scott H; Hogan, Brigid LM (Dis Model Mech, 2010-09)
      The small airways of the human lung undergo pathological changes in pulmonary disorders, such as chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis obliterans and cystic fibrosis. These clinical problems ...
    • BMP signaling in the development of the mouse esophagus and forestomach. 

      Rodriguez, Pavel; Da Silva, Susana; Oxburgh, Leif; Wang, Fan; Hogan, Brigid LM; Que, Jianwen (Development, 2010-12)
      The stratification and differentiation of the epidermis are known to involve the precise control of multiple signaling pathways. By contrast, little is known about the development of the mouse esophagus and forestomach, ...
    • Evidence that SOX2 overexpression is oncogenic in the lung. 

      Lu, Yun; Futtner, Christopher; Rock, Jason R; Xu, Xia; Whitworth, Walter; Hogan, Brigid LM; Onaitis, Mark W (PLoS One, 2010-06-10)
      BACKGROUND: SOX2 (Sry-box 2) is required to maintain a variety of stem cells, is overexpressed in some solid tumors, and is expressed in epithelial cells of the lung. METHODOLOGY/PRINCIPAL FINDINGS: We show that SOX2 is ...
    • Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. 

      Jain, Rajan; Barkauskas, Christina E; Takeda, Norifumi; Bowie, Emily J; Aghajanian, Haig; Wang, Qiaohong; Padmanabhan, Arun; ... (14 authors) (Nature communications, 2015-04-13)
      The plasticity of differentiated cells in adult tissues undergoing repair is an area of intense research. Pulmonary alveolar type II cells produce surfactant and function as progenitors in the adult, demonstrating ...
    • Type 2 alveolar cells are stem cells in adult lung. 

      Barkauskas, Christina E; Cronce, Michael J; Rackley, Craig R; Bowie, Emily J; Keene, Douglas R; Stripp, Barry R; Randell, Scott H; ... (9 authors) (The Journal of clinical investigation, 2013-07)
      Gas exchange in the lung occurs within alveoli, air-filled sacs composed of type 2 and type 1 epithelial cells (AEC2s and AEC1s), capillaries, and various resident mesenchymal cells. Here, we use a combination of in vivo ...