Browsing by Author "Howell, Bryan"
Now showing items 1-10 of 10
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Creating and parameterizing patient-specific deep brain stimulation pathway-activation models using the hyperdirect pathway as an example.
(PloS one, 2017-01)<h4>Background</h4>Deep brain stimulation (DBS) is an established clinical therapy and computational models have played an important role in advancing the technology. Patient-specific DBS models are now common tools in both ... -
Design and in vivo evaluation of more efficient and selective deep brain stimulation electrodes.
(Journal of neural engineering, 2015-08)<h4>Objective</h4>Deep brain stimulation (DBS) is an effective treatment for movement disorders and a promising therapy for treating epilepsy and psychiatric disorders. Despite its clinical success, the efficiency and selectivity ... -
Design of Electrodes for Efficient and Selective Electrical Stimulation of Nervous Tissue
(2015)Modulation of neural activity with electrical stimulation is a widespread therapy for treating neurological disorders and diseases. Two notable applications that have had striking clinical success are deep brain stimulation ... -
Effects of frequency-dependent membrane capacitance on neural excitability.
(Journal of neural engineering, 2015-10)<h4>Objective</h4>Models of excitable cells consider the membrane specific capacitance as a ubiquitous and constant parameter. However, experimental measurements show that the membrane capacitance declines with increasing ... -
Evaluation of high-perimeter electrode designs for deep brain stimulation.
(Journal of neural engineering, 2014-08)<h4>Objective</h4>Deep brain stimulation (DBS) is an effective treatment for movement disorders and a promising therapy for treating epilepsy and psychiatric disorders. Despite its clinical success, complications including ... -
Evaluation of intradural stimulation efficiency and selectivity in a computational model of spinal cord stimulation.
(PloS one, 2014-01)Spinal cord stimulation (SCS) is an alternative or adjunct therapy to treat chronic pain, a prevalent and clinically challenging condition. Although SCS has substantial clinical success, the therapy is still prone to failures, ... -
Feasibility of Interferential and Pulsed Transcranial Electrical Stimulation for Neuromodulation at the Human Scale.
(Neuromodulation : journal of the International Neuromodulation Society, 2021-07)<h4>Objectives</h4>Transcranial electrical stimulation (tES) is a promising tool for modulating neural activity, but tES has poor penetrability and spatiotemporal resolution compared to invasive techniques like deep brain ... -
Influences of interpolation error, electrode geometry, and the electrode-tissue interface on models of electric fields produced by deep brain stimulation.
(IEEE transactions on bio-medical engineering, 2014-02)Deep brain stimulation (DBS) is an established therapy for movement disorders, but the fundamental mechanisms by which DBS has its effects remain unknown. Computational models can provide insights into the mechanisms of ... -
Stimulation Efficiency With Decaying Exponential Waveforms in a Wirelessly Powered Switched-Capacitor Discharge Stimulation System.
(IEEE transactions on bio-medical engineering, 2018-05)The purpose of this study was to test the feasibility of using a switched-capacitor discharge stimulation (SCDS) system for electrical stimulation, and, subsequently, determine the overall energy saved compared to a conventional ... -
StimVision v2: Examples and Applications in Subthalamic Deep Brain Stimulation for Parkinson's Disease.
(Neuromodulation : journal of the International Neuromodulation Society, 2021-02)<h4>Objective</h4>Subthalamic deep brain stimulation (DBS) is an established therapy for Parkinson's disease. Connectomic DBS modeling is a burgeoning subfield of research aimed at characterizing the axonal connections activated ...
