Now showing items 1-4 of 4

    • Age-specific differences in oncogenic pathway deregulation seen in human breast tumors. 

      Anders, Carey K; Acharya, Chaitanya R; Hsu, David S; Broadwater, Gloria; Garman, Katherine; Foekens, John A; Zhang, Yi; ... (14 authors) (PLoS One, 2008-01-02)
      PURPOSE: To define the biology driving the aggressive nature of breast cancer arising in young women. EXPERIMENTAL DESIGN: Among 784 patients with early stage breast cancer, using prospectively-defined, age-specific cohorts ...
    • Development of a Novel c-MET-Based CTC Detection Platform. 

      Zhang, Tian; Boominathan, Rengasamy; Foulk, Brad; Rao, Chandra; Kemeny, Gabor; Strickler, John H; Abbruzzese, James L; ... (20 authors) (Mol Cancer Res, 2016-06)
      UNLABELLED: Amplification of the MET oncogene is associated with poor prognosis, metastatic dissemination, and drug resistance in many malignancies. We developed a method to capture and characterize circulating tumor cells ...
    • MYC activity mitigates response to rapamycin in prostate cancer through eukaryotic initiation factor 4E-binding protein 1-mediated inhibition of autophagy. 

      Balakumaran, Bala S; Porrello, Alessandro; Hsu, David S; Glover, Wayne; Foye, Adam; Leung, Janet Y; Sullivan, Beth A; ... (10 authors) (Cancer Res, 2009-10-01)
      Loss of PTEN and activation of phosphoinositide 3-kinase are commonly observed in advanced prostate cancer. Inhibition of mammalian target of rapamycin (mTOR), a downstream target of phosphoinositide 3-kinase signaling, ...
    • Single-Cell Transcriptomics Reveals Heterogeneity and Drug Response of Human Colorectal Cancer Organoids. 

      Chen, Kai-Yuan; Srinivasan, Tara; Lin, Christopher; Tung, Kuei-Ling; Gao, Ziyang; Hsu, David S; Lipkin, Steven M; ... (8 authors) (Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2018-07)
      Organoids are three-dimensional cell cultures that mimic organ functions and structures. The organoid model has been developed as a versatile in vitro platform for stem cell biology and diseases modeling. Tumor organoids ...