Browsing by Author "Huang, Nai-Jia"

Now showing items 1-4 of 4

    • Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11. 

      Chen, Chen; Zhang, Liguo; Huang, Nai-Jia; Huang, Bofu; Kornbluth, Sally (Proc Natl Acad Sci U S A, 2013-12-17)
      Ataxia telangiectasia mutant (ATM) is an S/T-Q-directed kinase that is critical for the cellular response to double-stranded breaks (DSBs) in DNA. Following DNA damage, ATM is activated and recruited by the MRN protein complex ...

    • The role of TRIM39 in cell cycle and apoptosis 

      Huang, Nai-Jia (2013)
      Within individual cells, the opposing processes of proliferation and apoptosis are precisely regulated. When this regulatory balance is interrupted, cells may become abnormal or even transformed. Understanding how to reverse ...

    • The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. 

      Huang, Nai-Jia; Zhang, Liguo; Tang, Wanli; Chen, Chen; Yang, Chih-Sheng; Kornbluth, Sally (J Cell Biol, 2012-04-30)
      Proapoptotic Bcl-2 family members, such as Bax, promote release of cytochrome c from mitochondria, leading to caspase activation and cell death. It was previously reported that modulator of apoptosis protein 1 (MOAP-1), ...

    • Ubiquitylation of p53 by the APC/C inhibitor Trim39. 

      Zhang, Liguo; Huang, Nai-Jia; Chen, Chen; Tang, Wanli; Kornbluth, Sally (Proc Natl Acad Sci U S A, 2012-12-18)
      Tripartite motif 39 (Trim39) is a RING domain-containing E3 ubiquitin ligase able to inhibit the anaphase-promoting complex (APC/C) directly. Through analysis of Trim39 function in p53-positive and p53-negative cells, we ...