Now showing items 1-3 of 3

    • Complex evolutionary trajectories of sex chromosomes across bird taxa. 

      An, N; Bachtrog, D; Gilbert, M Thomas P; Huang, Q; Jarvis, Erich David; Zhang, G; Zhang, J; ... (8 authors) (Science, 2014-12-12)
      Sex-specific chromosomes, like the W of most female birds and the Y of male mammals, usually have lost most genes owing to a lack of recombination. We analyze newly available genomes of 17 bird species representing the avian ...
    • Single-cell microarray enables high-throughput evaluation of DNA double-strand breaks and DNA repair inhibitors. 

      Engelward, BP; Floyd, Scott Richard; Ge, J; Huang, Q; Mutamba, JT; Rowland, EA; Weingeist, DM; ... (9 authors) (Cell Cycle, 2013-03-15)
      A key modality of non-surgical cancer management is DNA damaging therapy that causes DNA double-strand breaks that are preferentially toxic to rapidly dividing cancer cells. Double-strand break repair capacity is recognized ...
    • The bromodomain protein Brd4 insulates chromatin from DNA damage signalling. 

      Blake, EJ; Bradner, JE; Bryson, BD; Cannell, IG; Carpenter, AE; Chen, CC; Chen, GC; ... (24 authors) (Nature, 2013-06-13)
      DNA damage activates a signalling network that blocks cell-cycle progression, recruits DNA repair factors and/or triggers senescence or programmed cell death. Alterations in chromatin structure are implicated in the initiation ...