Browsing by Author "Huang, Yang Zhong"
Now showing items 1-3 of 3
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A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus.
(Neuron, 2015-11-04)The BDNF receptor tyrosine kinase, TrkB, underlies nervous system function in both health and disease. Excessive activation of TrkB caused by status epilepticus promotes development of temporal lobe epilepsy (TLE), revealing ... -
Regression of Epileptogenesis by Inhibiting Tropomyosin Kinase B Signaling following a Seizure.
(Annals of neurology, 2019-12)OBJECTIVE:Temporal lobe epilepsy (TLE) is a devastating disease in which seizures persist in 35% of patients despite optimal use of antiseizure drugs. Clinical and preclinical evidence implicates seizures themselves as one ... -
TrkB-Shc Signaling Protects against Hippocampal Injury Following Status Epilepticus.
(The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019-06)Temporal lobe epilepsy (TLE) is a common and commonly devastating form of human epilepsy for which only symptomatic therapy is available. One cause of TLE is an episode of de novo prolonged seizures [status epilepticus (SE)]. ...
