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Browsing by Author "Huang, Yuh-Chin T"
Now showing items 1-11 of 11
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Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A.
(Oncotarget, 2015-02)Afatinib has anti-tumor effect in non-small cell lung carcinoma (NSCLC) with epidermal growth factor receptor (EGFR) mutation. We found afatinib can also induce apoptosis in NSCLC cells without EGFR mutation through CIP2A ... -
Application of Machine Learning in Pulmonary Function Assessment Where Are We Now and Where Are We Going?
(Frontiers in physiology, 2021-01)Analysis of pulmonary function tests (PFTs) is an area where machine learning (ML) may benefit clinicians, researchers, and the patients. PFT measures spirometry, lung volumes, and carbon monoxide diffusion capacity of the ... -
Chronic hypersensitivity pneumonitis in the southeastern United States: an assessment of how clinicians reached the diagnosis.
(BMC pulmonary medicine, 2020-02-05)BACKGROUND:Chronic hypersensitivity pneumonitis (cHP) is a disease caused by exposure to inhaled environmental antigens. Diagnosis of cHP is influenced by the awareness of the disease prevalence, which varies significantly ... -
Controlled human exposures to ambient pollutant particles in susceptible populations.
(Environmental health : a global access science source, 2009-01)Epidemiologic studies have established an association between exposures to air pollution particles and human mortality and morbidity at concentrations of particles currently found in major metropolitan areas. The adverse ... -
Development and Evaluation of a Small Airway Disease Index Derived From Modeling the Late-Expiratory Flattening of the Flow-Volume Loop.
(Frontiers in physiology, 2022-01)Excessive decrease in the flow of the late expiratory portion of a flow volume loop (FVL) or "flattening", reflects small airway dysfunction. The assessment of the flattening is currently determined by visual inspection ... -
Discrimination of vanadium from zinc using gene profiling in human bronchial epithelial cells.
(Environmental health perspectives, 2005-12)We hypothesized that gene expression profiling may discriminate vanadium from zinc in human bronchial epithelial cells (HBECs). RNA from HBECs exposed to vehicle, V (50 microM), or Zn (50 microM) for 4 hr (n = 4 ... -
Exposure to concentrated coarse air pollution particles causes mild cardiopulmonary effects in healthy young adults.
(Environmental health perspectives, 2009-07)BACKGROUND: There is ample epidemiologic and toxicologic evidence that exposure to fine particulate matter (PM) air pollution [aerodynamic diameter < or = 2.5 microm (PM(2.5))], which derives primarily from combustion processes, ... -
Letters of Correspondence: Telehealth, Post-Acute Sequelae of COVID-19, Lung Cancer Screening Rates.
(North Carolina medical journal, 2022-03) -
Pollutant particles produce vasoconstriction and enhance MAPK signaling via angiotensin type I receptor.
(Environmental health perspectives, 2005-08)Exposure to particulate matter (PM) is associated with acute cardiovascular mortality and morbidity, but the mechanisms are not entirely clear. In this study, we hypothesized that PM may activate the angiotensin type 1 receptor ... -
Seasonal variations in air pollution particle-induced inflammatory mediator release and oxidative stress.
(Environmental health perspectives, 2005-08)Health effects associated with particulate matter (PM) show seasonal variations. We hypothesized that these heterogeneous effects may be attributed partly to the differences in the elemental composition of PM. Normal human ... -
Vanadyl sulfate inhibits NO production via threonine phosphorylation of eNOS.
(Environmental health perspectives, 2004-02)Exposure to excessive vanadium occurs in some occupations and with consumption of some dietary regimens for weight reduction and body building. Because vanadium is vasoactive, individuals exposed to excessive vanadium may ...
