Browsing by Author "Hughes, Philip"

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Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain.

Wang, Yaomin; Scarneo, Scott A; Kim, Shin Hyung; Zhang, Xin; Chen, Jiegen; Yang, Kelly W; Hughes, Philip; ... (9 authors) (Pain, 2021-10-12)

Heat shock protein 90 (Hsp90) is a ubiquitously expressed integral cellular protein essential for regulating proteomic stress. Previous research has shown that Hsp90 regulates critical signaling pathways underlying chronic ...
Transforming growth factor-β-activated kinase 1 (TAK1) mediates chronic pain and cytokine production in mouse models of inflammatory, neuropathic, and primary pain.

Scarneo, Scott; Zhang, Xin; Wang, Yaomin; Camacho-Domenech, Jose; Ricano, Jennifer; Hughes, Philip; Haystead, Tim; ... (8 authors) (The journal of pain, 2023-04)

The origin of chronic pain is linked to inflammation, characterized by increased levels of pro-inflammatory cytokines in local tissues and systemic circulation. Transforming growth factor beta-activated kinase 1 (TAK1) is ...