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    • Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions. 

      Wang, Donghai; Akula, Murali K; Ibrahim, Mohamed X; Ivarsson, Emil G; Khan, Omar M; Kumar, Israiel T; Erlandsson, Malin; ... (14 authors) (Nature communications, 2019-09-04)
      Rho family proteins are prenylated by geranylgeranyltransferase type I (GGTase-I), which normally target proteins to membranes for GTP-loading. However, conditional deletion of GGTase-I in mouse macrophages increases GTP-loading ...