Now showing items 1-2 of 2

    • Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A. 

      Wu, Judy Qiju; Hansen, David V; Guo, Yanxiang; Wang, Michael Zhuo; Tang, Wanli; Freel, Christopher D; Tung, Jeffrey J; ... (9 authors) (Proc Natl Acad Sci U S A, 2007-10-16)
      Before fertilization, vertebrate eggs are arrested in meiosis II by cytostatic factor (CSF), which holds the anaphase-promoting complex (APC) in an inactive state. It was recently reported that Mos, an integral component ...
    • Inhibition of the anaphase-promoting complex by the Xnf7 ubiquitin ligase. 

      Casaletto, Jessica B; Nutt, Leta K; Wu, Qiju; Moore, Jonathan D; Etkin, Laurence D; Jackson, Peter K; Hunt, Tim; ... (8 authors) (J Cell Biol, 2005-04-11)
      Degradation of specific protein substrates by the anaphase-promoting complex/cyclosome (APC) is critical for mitotic exit. We have identified the protein Xenopus nuclear factor 7 (Xnf7) as a novel APC inhibitor able to regulate ...