Now showing items 1-20 of 78

    • A Foxp2 Mutation Implicated in Human Speech Deficits Alters Sequencing of Ultrasonic Vocalizations in Adult Male Mice. 

      Chabout, Jonathan; Sarkar, Abhra; Patel, Sheel R; Radden, Taylor; Dunson, David B; Fisher, Simon E; Jarvis, Erich D (Front Behav Neurosci, 2016)
      Development of proficient spoken language skills is disrupted by mutations of the FOXP2 transcription factor. A heterozygous missense mutation in the KE family causes speech apraxia, involving difficulty producing words ...
    • A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes. 

      Wada, Kazuhiro; Howard, Jason T; McConnell, Patrick; Whitney, Osceola; Lints, Thierry; Rivas, Miriam V; Horita, Haruhito; ... (20 authors) (Proc Natl Acad Sci U S A, 2006-10-10)
      Songbirds have one of the most accessible neural systems for the study of brain mechanisms of behavior. However, neuroethological studies in songbirds have been limited by the lack of high-throughput molecular resources ...
    • A refined model of the genomic basis for phenotypic variation in vertebrate hemostasis. 

      Ribeiro, Ângela M; Zepeda-Mendoza, M Lisandra; Bertelsen, Mads F; Kristensen, Annemarie T; Jarvis, Erich D; Gilbert, M Thomas P; da Fonseca, Rute R (BMC Evol Biol, 2015-06-30)
      BACKGROUND: Hemostasis is a defense mechanism that enhances an organism's survival by minimizing blood loss upon vascular injury. In vertebrates, hemostasis has been evolving with the cardio-vascular and hemodynamic systems ...
    • Advances to Bayesian network inference for generating causal networks from observational biological data. 

      Yu, Jing; Smith, V Anne; Wang, Paul P; Hartemink, Alexander J; Jarvis, Erich D (Bioinformatics, 2004-12-12)
      MOTIVATION: Network inference algorithms are powerful computational tools for identifying putative causal interactions among variables from observational data. Bayesian network inference algorithms hold particular promise ...
    • Analysis of the mouse transcriptome for genes involved in the function of the nervous system. 

      Gustincich, Stefano; Batalov, Serge; Beisel, Kirk W; Bono, Hidemasa; Carninci, Piero; Fletcher, Colin F; Grimmond, Sean; ... (22 authors) (Genome Res, 2003-06)
      We analyzed the mouse Representative Transcript and Protein Set for molecules involved in brain function. We found full-length cDNAs of many known brain genes and discovered new members of known brain gene families, including ...
    • Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species. 

      Bradnam, Keith R; Fass, Joseph N; Alexandrov, Anton; Baranay, Paul; Bechner, Michael; Birol, Inanç; Boisvert, Sébastien; ... (92 authors) (Gigascience, 2013-07-22)
      BACKGROUND: The process of generating raw genome sequence data continues to become cheaper, faster, and more accurate. However, assembly of such data into high-quality, finished genome sequences remains challenging. Many ...
    • Assessing visual requirements for social context-dependent activation of the songbird song system. 

      Hara, Erina; Kubikova, Lubica; Hessler, Neal A; Jarvis, Erich D (Proc Biol Sci, 2009-01-22)
      Social context has been shown to have a profound influence on brain activation in a wide range of vertebrate species. Best studied in songbirds, when males sing undirected song, the level of neural activity and expression ...
    • Avian brains and a new understanding of vertebrate brain evolution. 

      Jarvis, Erich D; Güntürkün, Onur; Bruce, Laura; Csillag, András; Karten, Harvey; Kuenzel, Wayne; Medina, Loreta; ... (30 authors) (Nat Rev Neurosci, 2005-02)
      We believe that names have a powerful influence on the experiments we do and the way in which we think. For this reason, and in the light of new evidence about the function and evolution of the vertebrate brain, an international ...
    • Avian genomes. A flock of genomes. Introduction. 

      Zhang, Guojie; Jarvis, Erich D; Gilbert, M Thomas P (Science, 2014-12-12)
    • Basal ganglia function, stuttering, sequencing, and repair in adult songbirds. 

      Kubikova, Lubica; Bosikova, Eva; Cvikova, Martina; Lukacova, Kristina; Scharff, Constance; Jarvis, Erich D (Sci Rep, 2014-10-13)
      A pallial-basal-ganglia-thalamic-pallial loop in songbirds is involved in vocal motor learning. Damage to its basal ganglia part, Area X, in adult zebra finches has been noted to have no strong effects on song and its function ...
    • Brain evolution by brain pathway duplication. 

      Chakraborty, Mukta; Jarvis, Erich D (Philos Trans R Soc Lond B Biol Sci, 2015-12-19)
      Understanding the mechanisms of evolution of brain pathways for complex behaviours is still in its infancy. Making further advances requires a deeper understanding of brain homologies, novelties and analogies. It also requires ...
    • Comparative genomic data of the Avian Phylogenomics Project. 

      Zhang, Guojie; Li, Bo; Li, Cai; Gilbert, M Thomas P; Jarvis, Erich D; Wang, Jun; Wang, Jun; ... (8 authors) (2014)
      BACKGROUND: The evolutionary relationships of modern birds are among the most challenging to understand in systematic biology and have been debated for centuries. To address this challenge, we assembled or collected the ...
    • Comparative genomics based on massive parallel transcriptome sequencing reveals patterns of substitution and selection across 10 bird species. 

      Künstner, Axel; Wolf, Jochen BW; Backström, Niclas; Whitney, Osceola; Balakrishnan, Christopher N; Day, Lainy; Edwards, Scott V; ... (13 authors) (Mol Ecol, 2010-03)
      Next-generation sequencing technology provides an attractive means to obtain large-scale sequence data necessary for comparative genomic analysis. To analyse the patterns of mutation rate variation and selection intensity ...
    • Comparative genomics reveals molecular features unique to the songbird lineage. 

      Wirthlin, Morgan; Lovell, Peter V; Jarvis, Erich D; Mello, Claudio V (BMC Genomics, 2014-12-13)
      BACKGROUND: Songbirds (oscine Passeriformes) are among the most diverse and successful vertebrate groups, comprising almost half of all known bird species. Identifying the genomic innovations that might be associated with ...
    • Complex evolutionary trajectories of sex chromosomes across bird taxa. 

      Zhou, Qi; Zhang, Jilin; Bachtrog, Doris; An, Na; Huang, Quanfei; Jarvis, Erich D; Gilbert, M Thomas P; ... (8 authors) (Science, 2014-12-12)
      Sex-specific chromosomes, like the W of most female birds and the Y of male mammals, usually have lost most genes owing to a lack of recombination. We analyze newly available genomes of 17 bird species representing the avian ...
    • Computational inference of neural information flow networks. 

      Smith, V Anne; Yu, Jing; Smulders, Tom V; Hartemink, Alexander J; Jarvis, Erich D (PLoS Comput Biol, 2006-11-24)
      Determining how information flows along anatomical brain pathways is a fundamental requirement for understanding how animals perceive their environments, learn, and behave. Attempts to reveal such neural information flow ...
    • Convergent differential regulation of parvalbumin in the brains of vocal learners. 

      Hara, Erina; Rivas, Miriam V; Ward, James M; Okanoya, Kazuo; Jarvis, Erich D (PLoS One, 2012)
      Spoken language and learned song are complex communication behaviors found in only a few species, including humans and three groups of distantly related birds--songbirds, parrots, and hummingbirds. Despite their ...
    • Convergent differential regulation of SLIT-ROBO axon guidance genes in the brains of vocal learners. 

      Wang, Rui; Chen, Chun-Chun; Hara, Erina; Rivas, Miriam V; Roulhac, Petra L; Howard, Jason T; Chakraborty, Mukta; ... (9 authors) (J Comp Neurol, 2015-04-15)
      Only a few distantly related mammals and birds have the trait of complex vocal learning, which is the ability to imitate novel sounds. This ability is critical for speech acquisition and production in humans, and is attributed ...
    • Convergent transcriptional specializations in the brains of humans and song-learning birds. 

      Pfenning, Andreas R; Hara, Erina; Whitney, Osceola; Rivas, Miriam V; Wang, Rui; Roulhac, Petra L; Howard, Jason T; ... (25 authors) (Science, 2014-12-12)
      Song-learning birds and humans share independently evolved similarities in brain pathways for vocal learning that are essential for song and speech and are not found in most other species. Comparisons of brain transcriptomes ...
    • Core and region-enriched networks of behaviorally regulated genes and the singing genome. 

      Whitney, Osceola; Pfenning, Andreas R; Howard, Jason T; Blatti, Charles A; Liu, Fang; Ward, James M; Wang, Rui; ... (14 authors) (Science, 2014-12-12)
      Songbirds represent an important model organism for elucidating molecular mechanisms that link genes with complex behaviors, in part because they have discrete vocal learning circuits that have parallels with those that ...