Now showing items 1-4 of 4

    • Baseline Pulse Pressure, Acute Kidney Injury, and Mortality After Noncardiac Surgery. 

      Oprea, Adriana D; Lombard, Frederick W; Liu, Wen-Wei; White, William D; Karhausen, Jörn A; Li, Yi-Ju; Miller, Timothy E; ... (11 authors) (Anesth Analg, 2016-12)
      BACKGROUND: Increased pulse pressure (PP) is an important independent predictor of cardiovascular outcome and acute kidney injury (AKI) after cardiac surgery. The objective of this study was to determine whether elevated ...
    • Mast cell activation and arterial hypotension during proximal aortic repair requiring hypothermic circulatory arrest. 

      Kertai, Miklos D; Cheruku, Sreekanth; Qi, Wenjing; Li, Yi-Ju; Hughes, G Chad; Mathew, Joseph P; Karhausen, Jörn A (J Thorac Cardiovasc Surg, 2017-01)
      OBJECTIVE: Aortic surgeries requiring hypothermic circulatory arrest evoke systemic inflammatory responses that often manifest as vasoplegia and hypotension. Because mast cells can rapidly release vasoactive and proinflammatory ...
    • Platelet Counts and Postoperative Stroke After Coronary Artery Bypass Grafting Surgery. 

      Karhausen, Jörn A; Smeltz, Alan M; Akushevich, Igor; Cooter, Mary; Podgoreanu, Mihai V; Stafford-Smith, Mark; Martinelli, Susan M; ... (9 authors) (Anesth Analg, 2017-06-17)
      BACKGROUND: Declining platelet counts may reveal platelet activation and aggregation in a postoperative prothrombotic state. Therefore, we hypothesized that nadir platelet counts after on-pump coronary artery bypass grafting ...
    • Platelet Counts, Acute Kidney Injury, and Mortality after Coronary Artery Bypass Grafting Surgery. 

      Kertai, Miklos D; Zhou, Shan; Karhausen, Jörn A; Cooter, Mary; Jooste, Edmund; Li, Yi-Ju; White, William D; ... (15 authors) (Anesthesiology, 2016-02)
      BACKGROUND: Cardiac surgery requiring cardiopulmonary bypass is associated with platelet activation. Because platelets are increasingly recognized as important effectors of ischemia and end-organ inflammatory injury, the ...